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7 mg nickel/m3 as nickel subsulfide (6 hours/day, 5 days/week) for 78 weeks also did not affect the microscopic appearance of the intestines (Ottolenghi et al. 1974). Hematological Effects. No studies were located regarding hematological effects in humans after inhalation exposure to nickel. 8 mg nickel/m3 (Weischer et al. 1980). 8 mg nickel/m3 during nonbreeding periods. Male rats were not exposed to the high concentrations of nickel which resulted in increased hematocrits in female rats, and female rats were not exposed to the low concentrations of nickel that resulted in decreased hematocrits in male rats.

9 NTP 1996a oxide TABLE 2-1. 9 NTP 1996a oxide Cancer 66 Human occupational >10 M (CEL: lung and nasal cancers) Int Committee on Ni Carcinogenesis in Man 1990 less soluble 67 Rat (Fischer-344) 2 yr 5d/wk 6hr/d 1 (CEL: 12/106 alveolar/bronchiolar adenoma or carcinoma) 2 (CEL: 53/108 benign or malignant pheochromocytoma of the adrenal medulla) Dunnick et al. 11 Dunnick et al. 11 M (CEL: 30/53 benign or malignant pheochromocytoma of the adrenal medulla) TABLE 2-1. 7 (CEL: lung adenomas, adenocarcinomas, squamous cell carcinoma, 14% treated, 1% controls) a The numbers correspond to entries in Figure 2-1.

1988; NTP 1996a oxide Benson et al. 1987; Dunnick et al. 1988; NTP 1996b subsulfide TABLE 2-1. 6 (lung inflammation; atrophy of the olfactory epithelium) (lung inflammation) Reference/ Chemical form Benson et al. 1988; Dunnick et al. 1988; NTP 1996c sulfate Dunnick et al. 6 (atrophy of the thymus; hyperplasia of lymph nodes) Dunnick et al. 46 F (increased susceptibility to streptococcal infection) Adkins et al. 1979 chloride or sulfate TABLE 2-1. 6 (altrophy of the thymus; hyperplasia of the lymph nodes) Dunnick et al.

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