New PDF release: Toxicological profiles - Antimony and compounds


Read or Download Toxicological profiles - Antimony and compounds PDF

Best pharmacology books

Download PDF by Stephanie T. Weiss: High-Yield Pharmacology (3rd Edition) (High-Yield Series)

Now in its 3rd variation, High-Yield™ Pharmacology offers a succinct evaluate of pharmacology whereas clarifying tricky options. Need-to-know details is gifted in a transparent, concise define layout. extra beneficial properties comprise up to date drug references, a drug index, key issues in daring, and tables summarizing key evidence.

Emilio Benfenati's In Silico Methods for Predicting Drug Toxicity PDF

This designated quantity explores in silico equipment for pharmaceutical toxicity by means of combining the theoretical complex learn with the sensible software of the instruments. starting with a bit overlaying refined versions addressing the binding to receptors, pharmacokinetics and adsorption, metabolism, distribution, and excretion, the e-book maintains with chapters delving into versions for particular toxicological and ecotoxicological endpoints, in addition to large perspectives of the most tasks and new views in an effort to potentially enhance our approach of modelling prescription drugs.

Additional info for Toxicological profiles - Antimony and compounds

Example text

Because neurological effects have been observed in three species of animals (dogs, rats, and mice), these effects may also occur in humans exposed to high levels of antimony. Developmental Effects. An increase in the number of spontaneous abortions was observed in women exposed to airborne antimony in the workplace. The exposure level was not reported in this study. No overt developmental effects were observed in the children of these women (Belyaeva 1967). No gross abnormalities were observed in the offspring of rats exposed to low levels of antimony trichloride in the drinking water (Rossi et al.

1954). In addition, altered EKG readings have been reported in individuals exposed to repeated injections of antimony (Dancaster et al. 1966; Honey 1960; Pandey et al. 1988). The antimony injections were part of a therapeutic treatment for parasitic disease. In some of these individuals, the EKG did not return to normal until 6 weeks after the last dose (Dancaster et al. 1966). Pentavalent antimony appears to be less cardiotoxic than the trivalent form. 98 mg antimony/kg/day) (Dancaster et al. 2 mg antimony/kg/day) (Pandey et al.

The organic forms of antimony discussed are potassium antimony tartrate, sodium antimony tartrate, and antimony acetate. Also included are the antimony-containing drugs stibocaptate (sodium antimony-2,3-meso-di-mercapto succinate) also referred to as astiban, and stibophen (bis[4,5-dihydroxy- 1,3benzenedisulfonato(4)-O4, O5]-antimonate (5-) pentasodium heptahydrate) also called fuadin. Trivalent inorganic antimony compounds (antimony trioxide, antimony trichloride, antimony trisulfide), pentavalent inorganic compounds (antimony pentoxide, antimony pentachloride, and antimony pentasulfide), and stibine are also discussed.

Download PDF sample

Toxicological profiles - Antimony and compounds

by Richard

Rated 4.19 of 5 – based on 48 votes