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Additional info for Toxicological profiles - Antimony and compounds
Example text
Because neurological effects have been observed in three species of animals (dogs, rats, and mice), these effects may also occur in humans exposed to high levels of antimony. Developmental Effects. An increase in the number of spontaneous abortions was observed in women exposed to airborne antimony in the workplace. The exposure level was not reported in this study. No overt developmental effects were observed in the children of these women (Belyaeva 1967). No gross abnormalities were observed in the offspring of rats exposed to low levels of antimony trichloride in the drinking water (Rossi et al.
1954). In addition, altered EKG readings have been reported in individuals exposed to repeated injections of antimony (Dancaster et al. 1966; Honey 1960; Pandey et al. 1988). The antimony injections were part of a therapeutic treatment for parasitic disease. In some of these individuals, the EKG did not return to normal until 6 weeks after the last dose (Dancaster et al. 1966). Pentavalent antimony appears to be less cardiotoxic than the trivalent form. 98 mg antimony/kg/day) (Dancaster et al. 2 mg antimony/kg/day) (Pandey et al.
The organic forms of antimony discussed are potassium antimony tartrate, sodium antimony tartrate, and antimony acetate. Also included are the antimony-containing drugs stibocaptate (sodium antimony-2,3-meso-di-mercapto succinate) also referred to as astiban, and stibophen (bis[4,5-dihydroxy- 1,3benzenedisulfonato(4)-O4, O5]-antimonate (5-) pentasodium heptahydrate) also called fuadin. Trivalent inorganic antimony compounds (antimony trioxide, antimony trichloride, antimony trisulfide), pentavalent inorganic compounds (antimony pentoxide, antimony pentachloride, and antimony pentasulfide), and stibine are also discussed.
Toxicological profiles - Antimony and compounds
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