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55d 57r 2. HEALTH EFFECTS 44r 44r 42r Canc Repro 51m 47m 100 ductiv l logica Neuro Weig Rena Body l tic 47m 43m 1000 Hepa Death 10000 Hema (mg/kg/day) ht tologic al Systemic Table 2-2 2,4- and 2,6-DINITROTOLUENE Figure 2-2. Levels of Significant Exposure to 2,6-Dinitrotoluene - Oral (mg/kg/day) 1000 3m 1r 100 Figure 2-2 Death Acute (≤14 days) 4m 2r 10 2. 0000001 Minimal risk level for effects other than cancer The number next to each point corresponds to entries in Table 2-2. * Doses represent the lowest dose tested per study that produced a tumorigenic response and do not imply the existence of a threshold for the cancer end point.

Two of 154 workers at a munitions plant suffered from acute hepatitis with jaundice but recovered soon after they were no longer exposed to 2,4-DNT (McGee et al. 1942). Although the exposure concentrations were not known, they were assumed to be high based upon the industrial hygiene practices prevalent at that time. Furthermore, since an adequate control population was not used, this study provides only a qualitative description of symptoms, at best. A later study of 714 workers at this same plant found that 29 experienced liver tenderness (McGee et al.

After feeding 51 mg/kg/day 2,6-DNT to male Swiss albino mice in the diet for up to 13 weeks, 8 of 16 of these animals died; 6 of 16 females fed 55 mg/kg/day 2,6-DNT also died (Lee et al. 1976). No treatment-related deaths were reported when rats were fed up to 155 mg/kg/day 2,6-DNT for the same duration (Lee et al. 1976). Two of 8 dogs treated with 20 mg/kg 2,6-DNT by capsule died in a 13-week study (Lee et al. 1976). Thus, dogs seem to be the most sensitive of the three species to intermediate-duration oral 2,6-DNT exposure.

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Toxicological profiles - 2,4- and 2,6-dinitrotoluene

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