New PDF release: Target Discovery and Validation Reviews and Protocols, Vol


By Mouldy, Ed. Sioud

ISBN-10: 1588298906

ISBN-13: 9781588298904

ISBN-10: 1597452084

ISBN-13: 9781597452083

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Extra resources for Target Discovery and Validation Reviews and Protocols, Vol 2: Emerging Molecular Targets and Treatment Options (Methods in Molecular Biology Vol 361)

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Activation status of major signaling pathways in breast cancer cells. Cyoplasmic protein extracts were prepared from the breast cancer cell line SKBR3 or normal human mammary epithelial cells and then analyzed by Western blotting. Both total and phosphorylated kinases were detected using commercially available specific antibodies. 18 Sioud and Leirdal Table 4 Anticancer Agents Targeting PKC and Bcl-2 Drug ISIS3521 G3139 Type Target Antisense Antisense PKCα Bcl-2 Malignancies NSCLC, solid tumors Melanoma, MM, CLL, NSCLC Development phase I-III III activation status of the four main signaling proteins, p38, ERK, PKCα, and AKT in SKBR3 breast cancer cell line and human mammary epithelial cells.

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Oncol. 19, S32–S40. 20. Nicholson, R. , Gee, J. , and Harper, M. E. (2001) EGFR and cancer prognosis. Eur. J. Cancer 37, 9–15. 21. , and Stanton, P. (2001) The value of the human epidermal growth factor receptor-2 (Her-2) as a prognostic marker. Eur. J. Cancer. 37, 3–10. 22. Chakravarti, A. , and Mehta, M. (2004) The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data. Int. J. Rad. Oncol.

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Target Discovery and Validation Reviews and Protocols, Vol 2: Emerging Molecular Targets and Treatment Options (Methods in Molecular Biology Vol 361) by Mouldy, Ed. Sioud

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