Molecular Biology and Physiology of Insulin and Insulin-Like - download pdf or read online
By J. S. Sussenbach, P. H. Steenbergh, E. Jansen, P. Holthuizen, D. Meinsma (auth.), Mohan K. Raizada, Derek LeRoith (eds.)
This quantity addresses a primary puzzle in biology and medication, particularly, how does tissue advance, fix and change itself. the reply seems to lie in progress elements and their law. To thrive and continue to exist we'd like development elements and this e-book concentrates on elements which are concerning progress hormone. development hormone doesn't act at once on all tissues, yet mediates a lot of its activities in the course of the unlock of insulin-like development components from the liver. the expansion components have been initially referred to as somatomedins by means of McConaghey and Sledge (1), who chanced on that they mediated growth-like results of development hormone. notwithstanding, the standards have been purified at the foundation in their insulinomimetic activities on fats and muscle and it truly is their dating to the insulin relations of pep tides that now supplies them their identify (2,3) of insulin-like progress components (IGFs). They mediate the activities of. development hormone at the proteoglycan synthesis of cartilage and convey mitogenic results in fibroblast cultures.
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Additional info for Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors
Roth, R. , 1988, Structure of the receptor for insulin-like growth factor II: the puzzle amplified. Science, 239:1269. Schwartz, T. , 1986, The processing of peptide precursors. Proline-directed arginyl cleavage and other monobasic processing mechanisms. , 200:1. Scott, C. , and Baxter, R. , 1990, Insulin-like growth factor-II/Mannose-6phosphate receptors are increased in hepatocytes from regenerating rat liver. Endocrinology, 126:2543. Steiner, D. , Quinn, P. , Chan, S. , and Tager, H. , 1980, Processing mechanisms in the biosynthesis of proteins.
4-kbp. , 1988). 0-kb species is derived from promoter P2, consists of exons 4, 5, 6 and 7. 8-kb mRNA is derived from promoter P3. This mRNA consists of exons 4B, 5, 6 and 7. In this case, the translational apparatus is presented with two mRNAs with different 5' noncoding regions. In adult liver, P2 and P3 are inactive and transcription is controlled by promoter P1. 3-kb and consists of exons 1, 2, 3, 5, 6 and 7. Thus, the expression of the IGF-II gene is regulated in a tissue- and developmentspecific way.
In contrast, [Leu 60J IGF I has reduced affinity for the rat liver type 2 IGF receptor (3). The structural model of IGF I proposed by Blundell et al. (8) predicts that tyrosine 60 and isoleucine 43 maintain a Van der Waals interaction that is analogous to the interaction between isoleucine A2 and tyrosine A19 of insulin. These data suggest that the replacement of tyrosine 60 results in a conformational change or destabilization leading to loss in affinity for both types 1 and 2 IGF receptors. Replacement of two or more tyrosines results in a dramatic loss in type 1 receptor affinity.
Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors by J. S. Sussenbach, P. H. Steenbergh, E. Jansen, P. Holthuizen, D. Meinsma (auth.), Mohan K. Raizada, Derek LeRoith (eds.)