Serotonin: From Cell Biology to Pharmacology and - download pdf or read online
By M. M. Rapport (auth.), Rodolfo Paoletti, Paul M. Vanhoutte, Nicoletta Brunello, Franco M. Maggi (eds.)
This quantity represents the lawsuits ofthe invited lectures ofthe first overseas Symposium on "Serotonin from mobile Biology to Pharmacology and Therapeutics" which was once held in Florence on March 29 -Aprill, 1989. This assembly, held lower than the co-sponsorship of the Serotonin membership and the Fondazione Giovanni Lorenzini, represents the 1st try and compile scientists excited about the complexity of the motion of 5-hydroxytryptamine in the course of the physique and in quite a few species. for this reason this quantity offers the reader with the original review of the assets, results, receptors, physiological activities and pathological position of Serotonin. As such it will likely be of curiosity not just to the individual devoting herorhis learn efforts to the learn of 5-hydroxytryptamine but in addition to all students or even clinicians desirous to know the way the strong monoamine can modulate mobile features. To speed up the book of those complaints the Editors and the publishers have chosen the digicam prepared structure and feature refrained from a long refereeing strategy. therefore the medical content material of, and the critiques expressed within the chapters are the only accountability of the authors. The Editors Milan and Houston The Editors are looking to thank Mrs. H. Liepman and her employees at Kluwer for the recommended and effective dealing with of the manuscripts.
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This quantity represents the court cases ofthe invited lectures ofthe first overseas Symposium on "Serotonin from cellphone Biology to Pharmacology and Therapeutics" which used to be held in Florence on March 29 -Aprill, 1989. This assembly, held lower than the co-sponsorship of the Serotonin membership and the Fondazione Giovanni Lorenzini, represents the 1st try and collect scientists desirous about the complexity of the motion of 5-hydroxytryptamine through the physique and in numerous species.
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Additional info for Serotonin: From Cell Biology to Pharmacology and Therapeutics
And MJ. Berridge (1979) 'Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland. Biochem. J. 178: 45-58. Jafferji, S. H. Michell (1976) 'Stimulation ofphosphatidylinositol turnover by histamine, 5hydroxytryptamine and adrenaline in the longitudinal smooth muscle of guinea pig ileum. Biochem. Pharm. 25: 1429-30. R. Nahorski (1985) '5-hydrm:ytryptamine-stimulated inositol lipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants.
This would indicate that it is the 5HT2 receptor which is important for activating PI hydrolysis rat aorta. Also, experiments in which eukaryotic cells were transfected with a plasmid encoding the 5HT2 receptor provided proof that the 5HT2 receptor may be coupled to a PI-specific phospholipase C (Pritchett et aI, 1988). Despite this abundance of evidence documenting 5HTr receptor mediated PI metabolism, the functional significance of this biochemical pathway has proved difficult to elucidate. Role of PI hydrolysis in smooth muscle function.
20 2. 1. CELL CULTURE COS-7 and HeLa cells were grown as rnonolayers in DMEM (Gibco) supplemented with 10% fetal calf serum, penicillin (100 units/ml) and streptomycin (100 mg/ml), in 5 % C02 at 37'C. 2. Radioligand binding studies 5-HT1AR binding studies were carried out with [3Hj8-0H-DPAT as previously described (8). 3. Expression vector and cell transfection The expression vector pBC121G-21 was constructed as described (8). COS-7 cells were transfected with this plasmid using the DEAE-dextran method.
Serotonin: From Cell Biology to Pharmacology and Therapeutics by M. M. Rapport (auth.), Rodolfo Paoletti, Paul M. Vanhoutte, Nicoletta Brunello, Franco M. Maggi (eds.)