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2002; Kassis et al. 1983). The possibility of receptor reutilization, once its function has been performed, has been advanced for a long time, but it has been verified only in the case of glucocorticoid receptors (Munck et al. 1995). Very little is known of the details of that process. 8 Cross-Talk Signaling Numerous intracellular signaling pathways initiated in the membrane receptors include processes of phosphorylation (Aaronica et al. 1993; Munck et al. N. Díaz Chico et al. 1995). Eventually, nuclear receptors can act as substrata of phosphorylation– dephosphorylationin response to signals originating in other pathways.

1987; Nilsson et al. 2001). The receptor dimer, associated with the HRE, will attract other transcription factors, with which the protein–protein interaction is produced. Finally, they will come together with the RNA polymerase II and the remaining transcription factors that formed the preinitiator complex to complete the machinery of gene transcription. The role of the receptor dimer is, therefore, that of assuring the correct anchorage of the transcription factors in the promoter region of the gene so that the functional assembly of the machinery of gene transcription is produced.

1988). The arrival of the hormone activates the dimer in situ and inverts its role as regulator. 4 Role of Receptor–Hormone Response Element Complex The sequences of the HRE are situated in the promoter region of the gene. In a zone close by (less than 100 nucleotides away) and always between the HRE and the point of initiation of the transcription, there is a sequence rich in thymidine and adenosine (TATA, or its equivalent) on which the RNA polymerase II attaches itself (Beato et al. 1996; Beato 1989; Chin 1995; Gruber et al.

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