Download PDF by Paramjeet S. Bagga (auth.), Jeffrey Wilusz (eds.): Post-Transcriptional Gene Regulation


By Paramjeet S. Bagga (auth.), Jeffrey Wilusz (eds.)

ISBN-10: 1588297837

ISBN-13: 9781588297839

In Post-Transcriptional Gene Regulation, well known authors current present technical ways to such a lot points of post-transcriptional keep an eye on and supply an invaluable and flexible laboratory bench source. With chapters cut up into sections protecting bioinformatics, basic elements of the learn of RNA biology, and strategies for particular elements of RNA biology, the specialist authors have crammed the publication with priceless tips of the alternate, perfected of their state of the art laboratories.

This new quantity from the tools in Molecular Biology sequence is convinently divided into 3 sections. the 1st part provides a chain of bioinformatic ways to deal with using RNA databases and algorithms to the learn of post-transcriptional law regarding untranslated areas of transcripts. within the moment part, a chain of equipment acceptable to primary matters in mRNA biology are provided. those comprise RNA structure/function, mRNP research and novel tools for mRNA labeling and isolation. The 3rd portion of this quantity offers methodologies to review specific points of post-transcriptional keep an eye on. This part comprises tools for the examine of different splicing and three’ finish processing, mRNA localization, mRNA translation, mRNA balance and si/miRNA legislation. jointly, Post-Transcriptional Gene Regulation offers the reader with an invaluable and flexible laboratory bench source that would turn into a vital reference within the field.

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Nucleic Acids Res, 34, D173–D180. 29. M. M. (2005) Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition. Genes Dev, 19, 1315–1327. Bioinformatic Identification of Poly(A) Sites in Genomes 37 30. , Wilusz, J. and Tian, B. (2005) Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation. RNA, 11, 1485–1493. 31. M. and Tian, B. (2006) Prediction of mRNA polyadenylation sites by support vector machine.

Their poly(A) tails are usually shorter than canonical poly(A) tails, and may contain other nucleotides in addition to adenosines. the alignment of cDNA/EST sequences with the genome. Trace sequences can contain additional poly(A/T) regions that are absent in cDNA/ESTs. These regions are removed from sequences submitted to public cDNA/EST databases because of their low sequencing quality or low complexity (being consecutive As or Ts). This information can be recovered by the alignment of Trace sequences with their corresponding cDNA/ESTs.

2000) Preferential binding of fd gene 5 protein to tetraplex nucleic acid structures. J Mol Biol 301, 575–584. Bioinformatics of UTR 21 23. Huang, H. , Chien, C. , Jen, K. , and Huang, H. D. (2006) RegRNA: an integrated web server for identifying regulatory RNA motifs and elements. Nucleic Acids Res 34, W429–W434. 24. Macke, T. , Ecker, D. , Gutell, R. , Case, D. , and Sampath, R. (2001) RNAMotif, an RNA secondary structure definition and search algorithm. Nucleic Acids Res 29, 4724–4735. 25. , Berardini, T.

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Post-Transcriptional Gene Regulation by Paramjeet S. Bagga (auth.), Jeffrey Wilusz (eds.)

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