R. van Furth (auth.), Ralph van Furth (eds.)'s Mononuclear Phagocytes: Biology of Monocytes and Macrophages PDF


By R. van Furth (auth.), Ralph van Furth (eds.)

ISBN-10: 9048141710

ISBN-13: 9789048141715

ISBN-10: 9401580707

ISBN-13: 9789401580700

Mononuclear phagocytes, which come with macrophages, monocytes and their precursor cells, are crucial cells within the host defence opposed to micro-organisms and tumor cells.
over the past twenty-five years study at the biology of mononuclear phagocytes has elevated greatly. This stimulated Professor R. van Furth to arrange 5 overseas meetings in this topic in Leiden, the Netherlands. The edited lawsuits of those meethings have been released: in 1970 Mononuclear Phagocytes; in 1975 Mononuclear Phagocytes in Immunity, Infections and Pathology; in 1980 Mononuclear Phagocytes -- useful Aspects; and in 1985 Mononuclear Phagocytes -- features, body structure and Function. experiences of those volumes, released in foreign journals, praised them because the newest cutting-edge courses. The booklet of 1991 comprises 88 chapters written through greater than 2 hundred authors.

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Extra info for Mononuclear Phagocytes: Biology of Monocytes and Macrophages

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Injection of the 5C6 mAb led to the inhibition of recruitment of both PMN and monocytes to thioglycollate induced peritoneal exudates by 84 ± 3% at 1d and by 80 ± 7% at 4d, respectively (24). Additional evidence supporting the role of CR3-dependent recruitment to sites of non-specific inflammation can be illustrated in examining the responses to bacterial LPS. Experiments performed by A . Harmsen examined the recruitment of cells and increases in vascular permeability to aerosolised LPS and showed that both recruitment and increases in vascular permeability could be abolished by pretreatment of mice with the 5C6 mAb (23).

The op/op mouse also provides us with an excellent system in which to investigate the mechanisms regulation of CSF-l target cells in vivo . While several of these cell populations are depleted in op/op mice , there are other populations , including some tissue macrophages, decidual and trophoblastic cells, that appear to be present in relatively normal numbers in adult op/op mice and therefore do not absolutely require CSF-l. It is likely that other growth factors, particularly GM-CSF , are partly required, or can compensate for a requirement of CSF-l, for the regulation of these cell populations during development.

Bartelmez SH , Bra dley T R, Ber to ncello I, Mochizuki DY, T ushinski RJ , Sta nley E R , H apel AJ , Youn g IG , Kriegler A B, Hodgson GS . Interl eukin 1 plus inte rleukin 3 plus colony-stimulat ing facto r 1 are essentia l for clonal pro liferation of primitive myeloid bone marrow cells. Ex p Hematol 1989, 17:240-245. 26. Bar tocci A , Mastrogian nis DS, Migliorati G , Stockert RJ , Wolkoff AW, Stan ley E R . Macroph ages specifically regulate the concentratio n of their own grow th factor in Chapter 2 27.

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Mononuclear Phagocytes: Biology of Monocytes and Macrophages by R. van Furth (auth.), Ralph van Furth (eds.)

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