Reelin Glycoprotein: Structure, Biology and Roles in Health by Cheng-Chiu Huang, Gabriella D’Arcangelo (auth.), S. Hossein PDF


By Cheng-Chiu Huang, Gabriella D’Arcangelo (auth.), S. Hossein Fatemi M.D., Ph.D. (eds.)

ISBN-10: 0387767606

ISBN-13: 9780387767604

Reelin glycoprotein is a huge secretory protein with very important roles in embryogenesis and through grownup lifestyles. Reelin gene mutations or deficiency of the protein product reason irregular cortical improvement and reelin signaling impairment in mind. because the first discovery of the reelin mutant mouse in 1951 by way of Falconer, and later discovery of the gene for reelin in 1995, there was an explosion of recent wisdom approximately this significant molecule. Reelin Glycoprotein: constitution, Biology and Roles in future health and Disease, written by way of a global panel of specialists, summarizes the nation of the data on quite a few facets of reelin. subject matters contain the reelin gene and its receptors, downstream effector molecules in reelin signaling cascade, chemistry and constitution of reelin, comparative anatomy of reelin, presence of reelin in quite a few physique tissues, reelin mutations, and abnormalities of reelin construction in neuropsychiatric problems and melanoma. This publication will function a origin for research of this rising novel protein for all neuroscientists and clinicians.

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23:187–192. , and Schwartz, A. L. (1998). RAP, a novel type of ER chaperone. Trends Cell Biol. 8:272–276. 30 H. H. Bock and J. Herz Calderwood, D. , de Pereda, J. , McGlade, C. , Liddington, R. , and Ginsberg, M. H. (2003). Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling. Proc. Natl. Acad. Sci. USA100:2272–2277. Cam, J. , and Bu, G. (2006). Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.

And Tsai, L. H. (2001). A decade of CDK5. Nature Rev. Mol. Cell Biol. 2:749–759. Dietschy, J. , and Turley, S. D. (2004). Thematic review series: Brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45:1375–1397. , Olson, E. , Taglienti, M. , Walsh, C. , Kreidberg, J. , and Anton, E. S. (2000). Reelin binds alpha3beta1 integrin and inhibits neuronal migration. Neuron 27:33–44. , and Walsh, C. A. (2001). Protein–protein interactions, cytoskeletal regulation and neuronal migration.

And Spillantini, M. G. (2006). A century of Alzheimer’s disease. Science 314:777–781. , Nevitt, M. , Richardson, J. , and Herz, J. (2000). Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J. Biol. Chem. 275:25616–25624. Goudriaan, J. , Tacken, P. , Dahlmans, V. , Gijbels, M. , van Dijk, K. , Havekes, L. , and Jong, M. C. (2001). Protection from obesity in mice lacking the VLDL receptor.

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Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease by Cheng-Chiu Huang, Gabriella D’Arcangelo (auth.), S. Hossein Fatemi M.D., Ph.D. (eds.)

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