Download e-book for kindle: Molecular Biology of Diabetes: I. Autoimmunity and Genetics; by Massimo Pietropaolo, George S. Eisenbarth (auth.), Boris
By Massimo Pietropaolo, George S. Eisenbarth (auth.), Boris Draznin MD, PhD, Derek LeRoith MD, PhD (eds.)
In a swiftly evolving and intensely vital sector of scientific technology, it is usually tricky for the coed, instructor, and researcher to maintain abreast of the entire vital advances. the aim of Molecular Biology ofDiabetes, elements I and II is to deliver to those participants the newest wisdom of diabetes-related study in a accomplished, but concise demeanour. To this finish, we now have assembled chapters, written by means of lots of the world's specialists within the box, that we think compre hensively survey and synthesize a coherent figuring out of the topic. stories of the etiology of sort I and sort II diabetes are super intriguing and crucial, for the reason that we are hoping to at least one day hinder the illness utilizing gene treatment. those points are lined in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In style II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor mality of insulin secretion is assumed to be with regards to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre tion could be the the most important step within the pathogenesis of noninsulin-depen dent diabetes. during this quantity, we now have invited authors to explain their reports on all recognized elements affecting ~-cell functionality, together with autoimmunity and genetics of diabetes, in addition to molecular mecha nisms of insulin synthesis and secretion. within the previous few years, the main swiftly advancing sector of analysis in diabetes has been, in truth, with regards to insulin action.
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Extra info for Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion
Targets of Type I Diabetes 31 48. : Combined analysis of autoantibodies enhances prediction ofIDDM in islet cell antibody (ICA) positive relatives. Autoimmunity (suppl):67 (abstract), 1993. 49. Eisenbarth GS, Verge CF, Allen H, Rewers MJ: Perspectives in diabetes: The design of trials for the prevention of IDDM. Diabetes 42:941947, 1993. 50. Maul 00, French BT, van Venrooij WJ, Jimenez SA: Topoisomerase I identified by scleroderma 70 antisera: enrichment of topoisomerase I at the centromere in mouse mitotic cells before anaphase.
47. Pietropaolo M, Buelow R, Gianani R, Yu L, Eisenbarth GS: Independent assortment of biochemically defined autoantibodies in prediabetic relatives. J Immunoll50:166A (abstract), 1993. Targets of Type I Diabetes 31 48. : Combined analysis of autoantibodies enhances prediction ofIDDM in islet cell antibody (ICA) positive relatives. Autoimmunity (suppl):67 (abstract), 1993. 49. Eisenbarth GS, Verge CF, Allen H, Rewers MJ: Perspectives in diabetes: The design of trials for the prevention of IDDM.
Which humoral response to antigenes) is important as a predictive marker of IDDM? None of these questions, except for the use of islet autoantigens in prediction, can be answered to date. How can this plethora of autoantigens related to type I diabetes be rationalized? Comprehensive analysis of the repertoire of autoantibodies in systemic autoimmune diseases has revealed that most autoimmune diseases are associated with a spectrum of autoantibodies against specific subcellular antigens. This diversity of autoantibody species among different autoimmune diseases was difficult to rationalize until the molecular structure and subcellular localization of the autoantigens was discovered.
Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion by Massimo Pietropaolo, George S. Eisenbarth (auth.), Boris Draznin MD, PhD, Derek LeRoith MD, PhD (eds.)