Get Photosensitive Molecules for Controlling Biological Function PDF

Nonfiction 3

By James J. Chambers, Richard H. Kramer

ISBN-10: 1617790303

ISBN-13: 9781617790300

The improvement of latest photochemical instruments, a few synthesized through chemists and a few supplied through nature, is swiftly altering the best way neurobiological study is played within the sleek laboratory. In Photosensitive Molecules for Controlling organic Function, professional researchers within the box learn the main state of the art instruments at the moment on hand. Divided into 3 sections, this designated compendium beneficial properties suggestions related to ordinary photosensitive proteins, caged neurotransmitters, and small molecule photoswitches that bestow gentle sensitivity on ion channels and receptors. Written for the Neuromethods sequence, this quantity gains the kind of meticulous description and implementation recommendation that's the most important for buying optimum leads to the lab.

Authoritative and sensible, Photosensitive Molecules for Controlling organic Function offers an impartial comparability of a number of the photochemical instruments presently to be had for controlling neuronal task in an effort to relief scientists within the important aim of selecting the appropriate instruments for the proper job.

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Additional info for Photosensitive Molecules for Controlling Biological Function

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Callaway EM, Katz LC (1993) Photo­ stimulation using caged glutamate reveals functional circuitry in living brain slices. Proc Natl Acad Sci USA 90:7661–7665 128. Dalva MB, Katz LC (1994) Rearrangements of synaptic connections in visual cortex revealed by laser photostimulation. Science 265:255–258 129. Dantzker JL, Callaway EM (2000) Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons. Nat Neurosci 3:701–707 130. Shepherd GM, Stepanyants A, Bureau I, Chklovskii D, Svoboda K (2005) Geometric and functional organization of cortical circuits.

Bernardinelli Y, Haeberli C, Chatton JY (2005) Flash photolysis using a light emitting diode: an efficient, compact, and affordable solution. Cell Calcium 37:565–572 115. Venkataramani S, Davitt KM, Xu H, Zhang J, Song YK, Connors BW, Nurmikko AV (2007) Semiconductor ultra-violet lightemitting diodes for flash photolysis. J Neurosci Methods 160:5–9 116. Xu H, Zhang J, Davitt KM, Song Y, Nurmikko AV (2008) Application of bluegreen and ultraviolet micro-LEDs to biological imaging and detection. J Phys D Appl Phys 41:94013 117.

Ellis-Davies Abstract Since much of the life of cells is controlled by their chemistry, caged compounds can be used to intervene in this life in a myriad of specific ways. Organic chemists have synthesized the widest possible array of caged compounds for use by biologists. The smallest possible chemical unit (protons) to the “largest” (RNA and DNA) have been caged. Further, nonnatural products have been caged and used for blocking one aspect of cell function. Many caged compounds have been used for rapid activation of cell function, as uncaging often occurs in less than a millisecond.

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Photosensitive Molecules for Controlling Biological Function by James J. Chambers, Richard H. Kramer

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