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Extra resources for Herbal Pharmacology in the People's Republic of China: A Trip Report of the American Herbal Pharmacology Delegation

Example text

The department of natural products is carrying out work on steroids, polypeptides and proteins, nucleic acids, and the microbial oxidation of petroleum. It seems that about one third of the institute's technical staff is concerned with various aspects of natural-products chemistry. Of these, 30 chemists have been assigned to nucleotide chemistry, 17 to polypeptide chemistry, and others seemed concerned with steroid development (oral contraceptives), synthesis of protein sources, and fluorine polymer chemistry (for example, polytetrafluoroethylene).

The work was carried out mostly by classical methods of degradation. com this work was done, the group had no NMR spectrometer, and so it was only possible to propose this partial structure. The final placement of the second hydroxyl group at C22 was reported by the Russians. There was also a talk on the synthesis of (+) menthol from (+) piperitone. It was obvious these two pieces of research had been accomplished before the Cultural Revolution. Liu Chu-chin also described some of his earlier structure work with the Veratrum alkaloids.

Another drug-processing laboratory was concerned with the effects of various treatments of the herbs (such as "carbonization" and rate of drying) upon the pharmacological activity of the extracts. The organic chemistry laboratory was involved in a study of the active principles of an Artemisia species used traditionally for treating jaundice. The group reported that they had isolated several compounds, two of which showed choleretic activity - caffeic acid and p-hydroxyacetophenone. It was not clear whether these compounds had received significant clinical evaluation.

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