Richard M. Elledge, William L. McGuire (auth.), Robert B.'s Genes, Oncogenes, and Hormones: Advances in Cellular and PDF


By Richard M. Elledge, William L. McGuire (auth.), Robert B. Dickson, Marc E. Lippman (eds.)

ISBN-10: 146136552X

ISBN-13: 9781461365525

ISBN-10: 146153500X

ISBN-13: 9781461535003

Where do you start to appear for a contemporary, authoritative article at the analysis or administration of a selected malignancy? The few normal oncology textbooks are in most cases outdated. unmarried papers in really expert journals are informative yet seldom complete; those are extra usually initial experiences on a really constrained variety of sufferers. convinced basic journals often submit stable in-depth stories of melanoma themes, and released symposium lectures are usually the simplest overviews to be had. regrettably, those experiences and vitamins seem sporadically, and the reader can by no means ascertain whilst an issue of specified curiosity can be coated. melanoma therapy and learn is a sequence of authoritative volumes that goal to fulfill this desire. it truly is an try to identify a serious mass of oncology literature protecting nearly all oncology themes, revised often to maintain the insurance modern, and simply to be had on a unmarried library shelf or by way of a unmarried own subscription. we now have approached the matter within the following model: first, by means of dividing the oncology literature into particular subdivisions similar to lung melanoma, genitourinary melanoma, pediatric oncology, etc.; and moment, through asking eminent professionals in every one of those components to edit a quantity at the particular subject on an annual or biannual foundation. every one subject and tumor variety is roofed in a quantity showing usually and predictably, discussing present di­ agnosis, staging, markers, all sorts of therapy modalities, simple biology, and more.

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Extra info for Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer

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A TIE consensus sequence is also present in the interstitial collagenase gene, as well as other genes that are negatively regulated by TGF-B1 [30]. Such an element is not found in the sequenced regions of the 72-kDa type IV collagenase upstream element [29] and, consistent with this sequence information, the expression of the 72-kDa type IV collagenase is either unaffected or moderately upregulated by TGF-B1 treatment of human cell lines [33,51]. Although regulation by two agents represents only a small part of the overall picture of regulation in vivo, these studies serve to demonstrate how some members of the collagenase family may be coordinately regulated and expressed, and how others, specifically the 72-kDa type IV collagenase, may be expressed in an independent fashion.

2. The collagenase (matrix metalloproteinase) gene family Nearly 30 years after the first identification of collagenolytic activity in the tadpole tail [18], the cloning and sequencing of individual genes has revealed a family of related proteinases with substrate specificity for structural extracellular proteins, such as the collagens [19-24]. The collagenase gene family can be divided into three subgroups based on substrate preference: interstitial collagenases, stromelysins, and type IV collagenases/gelatinases.

Nature 348:699-704. 28. , Herrlich, P. (1987) 12-0-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is 38 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. mediated by an inducible enhancer element located in the 5'-flanking region. Mol. Cell. BioI. 7:2256-2266. , Tryggvason, K. (1990) Structure of the human type IV collagenase gene. J. BioI. Chern. 265:11077-11082. M. (1990) TGF-131 inhibition oftransin/stromelysin gene expression is mediated through a fos binding sequence.

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Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer by Richard M. Elledge, William L. McGuire (auth.), Robert B. Dickson, Marc E. Lippman (eds.)

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