Download e-book for iPad: Dihydropyridines: Progress in Pharmacology and Therapy by S. Kazda (auth.), Wolf-Dieter Busse Ph.D., Bernward Garthoff
By S. Kazda (auth.), Wolf-Dieter Busse Ph.D., Bernward Garthoff DVM, Friedel Seuter Ph.D. (eds.)
ISBN-10: 3540573089
ISBN-13: 9783540573081
ISBN-10: 3642957161
ISBN-13: 9783642957161
This quantity studies vital milestones within the historical past of the advance of 1,4-dihydropyridines beginning within the overdue Sixties. the invention ended in theestablishment of Ca2+ antagonists as best cardiovascular medicinal drugs throughoutthe international. This quantity comprises shows of the result of a few contemporary collaborative extramural stories by means of American investigators.
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Extra info for Dihydropyridines: Progress in Pharmacology and Therapy
Example text
Figure 2 shows a typical example of w-CgTx applied to a central neuron. In this pyramidal neuron from the visual cortex, a saturating concentration of wCgTx blocked about 20% of the overall high-threshold calcium channel current. p. Type Calcium Channels There are other types of calcium channels in neurons besides L-type and Ntype channels. This can be seen in experiments in which high concentrations of dihydropyridines and w-CgTx are applied simultaneously. A typical example is shown in Fig. 2.
DE 3431 303. Goedecke AG 15. Hof RP, Ruegg UT, Hof A, Vogel A (1985) Stereoselektivity at the calcium channel: opposite action of the enantiomers of a l,4-dihydropyridine. J Cardiovasc Pharmacol7:689 16. Holtje HD, Marrer S (1987) A molecular graphics study on structure-action relationships of calcium-antagonistic and agonistic 1,4-dihydropyridines. P. M. Mintz Introduction Voltage-dependent calcium channels are present in all neurons. They are closed at normal resting potentials, and they open when a membrane is depolarized by an action potential.
In this pyramidal neuron from the visual cortex, a saturating concentration of wCgTx blocked about 20% of the overall high-threshold calcium channel current. p. Type Calcium Channels There are other types of calcium channels in neurons besides L-type and Ntype channels. This can be seen in experiments in which high concentrations of dihydropyridines and w-CgTx are applied simultaneously. A typical example is shown in Fig. 2. P. Bean and LM. Mintz -20mV 3IJM CgTx + 2,uM nimod 400pA 20 msec Fig. 2.
Dihydropyridines: Progress in Pharmacology and Therapy by S. Kazda (auth.), Wolf-Dieter Busse Ph.D., Bernward Garthoff DVM, Friedel Seuter Ph.D. (eds.)
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