Carrier-Based Drug Delivery - download pdf or read online


By Sönke Svenson

ISBN-10: 0841219842

ISBN-13: 9780841219847

ISBN-10: 0841238391

ISBN-13: 9780841238398

Carrier established Drug Delivery is split into 3 major sections that conceal significant provider structures used to carry medicinal drugs in addition to DNA. the 1st part describes using liposomes and tubules as service structures. The 8 chapters during this part document using stimuli-responsive liposomes and liposome-polymer complexes in drug and DNA supply, the appliance of impartial liposomes in gene move, and using niosomes within the supply of poorly soluble medications. The position of vesicle form in supply is mentioned, via experiences at the use of microtubules and templated nanotubes for the supply and separation of bioactives.

The moment part is dedicated to using polymeric micelles as targetable pharmaceutical vendors, novel therapeutics in drug supply, and endosomolytic brokers for gene supply. The part concludes with a bankruptcy at the use of ultrasound to enhance the potency of polymeric micelles as providers.

The 3rd part offers 9 chapters at the use of micro- and nanoparticulate vendors in drug supply. those chapters deal with how to organize specific micro- and nanoparticles, the usage of lipids in peptide and protein free up, and the development of nanocontainers, both by means of stabilization of liposomal templates or through layer-by-layer deposition of polymers round colloidal templates. The aid or prevention of burst free up from matrices is mentioned, in addition to using mucoadhesion and mechanical adhesion for localized nasal and peroral supply of actives.

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Sample text

In addition, these liposomes may facilitate cytoplasmic delivery of the drug by fusing with and/or destabilizing the endosomal membrane. The fate of pH-sensitive liposomes upon receptormediated endocytosis is illustrated in Figure 1. , oleic acid). Upon protonation of the negatively charged head group of the amphiphile in an acidic environment, DOPE reverts to non-bilayer structures, causing the release of the liposomal content. However, the instability of such vesicles constitutes a major drawback for possible in vivo applications, as rapid content leakage or substantial loss of pH-sensitivity has been observed in biological fluids.

16. ; Gregoriadis G. Life Sci. 1982, 30, 2123-2136. 17. ; Francis M . -C. Int. J. Pharm. 2002, In press. 18. ; Pezolet M . -C. J. Pharm. Sci. 2002, 91, 1795-1802. 19. -C. Canada Research Chair in Drug Delivery; Faculty of Pharmacy; Department of Chemistry. Universitéde Montréal. Unpublished data. 20. ; Papahadjopoulos D. Biochim. Biophys. Acta 1991, 1070, 187-192. 21. J. Proc. Natl. Acad. Sci. USA 1991, 88, 11460-11464. 22. ; Duzgunes N. J. Biol. Chem. 1997, 272, 2382-2388. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2004.

Preparation and characterization of solid lipid nanoparticles containing cloricromene. Drug Del. 2003, 10, 245-250. 103. ; Vauthier, C. Nanocapsule technology: A review. Crit. Rev. Ther. Drug Carrier Syst. 2002, 19, 99-134. 104. M. Effects of formulation variables on characteristics of poly(ethylcyanoacrylate) nanocapsulesfromw/o microemulsions. Int. J. Pharm. 2002, 235, 237-246. 105. S. Preparation and characterization of spray-dried polymeric nanocapsules. Drug Develop. Ind. Pharm. 2000, 26, 343-347.

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Carrier-Based Drug Delivery by Sönke Svenson

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