Carrier-Based Drug Delivery - download pdf or read online
By Sönke Svenson
ISBN-10: 0841219842
ISBN-13: 9780841219847
ISBN-10: 0841238391
ISBN-13: 9780841238398
Carrier established Drug Delivery is split into 3 major sections that conceal significant provider structures used to carry medicinal drugs in addition to DNA. the 1st part describes using liposomes and tubules as service structures. The 8 chapters during this part document using stimuli-responsive liposomes and liposome-polymer complexes in drug and DNA supply, the appliance of impartial liposomes in gene move, and using niosomes within the supply of poorly soluble medications. The position of vesicle form in supply is mentioned, via experiences at the use of microtubules and templated nanotubes for the supply and separation of bioactives.
The moment part is dedicated to using polymeric micelles as targetable pharmaceutical vendors, novel therapeutics in drug supply, and endosomolytic brokers for gene supply. The part concludes with a bankruptcy at the use of ultrasound to enhance the potency of polymeric micelles as providers.
The 3rd part offers 9 chapters at the use of micro- and nanoparticulate vendors in drug supply. those chapters deal with how to organize specific micro- and nanoparticles, the usage of lipids in peptide and protein free up, and the development of nanocontainers, both by means of stabilization of liposomal templates or through layer-by-layer deposition of polymers round colloidal templates. The aid or prevention of burst free up from matrices is mentioned, in addition to using mucoadhesion and mechanical adhesion for localized nasal and peroral supply of actives.
Read or Download Carrier-Based Drug Delivery PDF
Similar pharmacology books
New PDF release: High-Yield Pharmacology (3rd Edition) (High-Yield Series)
Now in its 3rd version, High-Yield™ Pharmacology presents a succinct assessment of pharmacology whereas clarifying tough ideas. Need-to-know info is gifted in a transparent, concise define structure. extra good points comprise up to date drug references, a drug index, key issues in daring, and tables summarizing key proof.
In Silico Methods for Predicting Drug Toxicity - download pdf or read online
This unique quantity explores in silico equipment for pharmaceutical toxicity by way of combining the theoretical complicated study with the sensible software of the instruments. starting with a bit overlaying refined versions addressing the binding to receptors, pharmacokinetics and adsorption, metabolism, distribution, and excretion, the publication maintains with chapters delving into versions for particular toxicological and ecotoxicological endpoints, in addition to large perspectives of the most tasks and new views in order to almost certainly increase our manner of modelling prescribed drugs.
- Pharmaceutical Experimental Design and Interpretation, 2nd Edition
- Medical Terminology: A Programmed Learning Approach to the Language of Health Care, 2nd Edition
- Desk Reference of Clinical Pharmacology
- Drug Injecting and HIV Infection (Social Aspects of Aids Series)
- Backen mit Hanf
Additional resources for Carrier-Based Drug Delivery
Sample text
In addition, these liposomes may facilitate cytoplasmic delivery of the drug by fusing with and/or destabilizing the endosomal membrane. The fate of pH-sensitive liposomes upon receptormediated endocytosis is illustrated in Figure 1. , oleic acid). Upon protonation of the negatively charged head group of the amphiphile in an acidic environment, DOPE reverts to non-bilayer structures, causing the release of the liposomal content. However, the instability of such vesicles constitutes a major drawback for possible in vivo applications, as rapid content leakage or substantial loss of pH-sensitivity has been observed in biological fluids.
16. ; Gregoriadis G. Life Sci. 1982, 30, 2123-2136. 17. ; Francis M . -C. Int. J. Pharm. 2002, In press. 18. ; Pezolet M . -C. J. Pharm. Sci. 2002, 91, 1795-1802. 19. -C. Canada Research Chair in Drug Delivery; Faculty of Pharmacy; Department of Chemistry. Universitéde Montréal. Unpublished data. 20. ; Papahadjopoulos D. Biochim. Biophys. Acta 1991, 1070, 187-192. 21. J. Proc. Natl. Acad. Sci. USA 1991, 88, 11460-11464. 22. ; Duzgunes N. J. Biol. Chem. 1997, 272, 2382-2388. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2004.
Preparation and characterization of solid lipid nanoparticles containing cloricromene. Drug Del. 2003, 10, 245-250. 103. ; Vauthier, C. Nanocapsule technology: A review. Crit. Rev. Ther. Drug Carrier Syst. 2002, 19, 99-134. 104. M. Effects of formulation variables on characteristics of poly(ethylcyanoacrylate) nanocapsulesfromw/o microemulsions. Int. J. Pharm. 2002, 235, 237-246. 105. S. Preparation and characterization of spray-dried polymeric nanocapsules. Drug Develop. Ind. Pharm. 2000, 26, 343-347.
Carrier-Based Drug Delivery by Sönke Svenson
by Christopher
4.3