Download e-book for kindle: Biochemical Pharmacology as an Approach to Gastrointestinal by K. D. Rainsford (auth.), Timothy S. Gaginella, Gyula Mózsik,
By K. D. Rainsford (auth.), Timothy S. Gaginella, Gyula Mózsik, K. D. Rainsford (eds.)
The Gastrointestinal portion of the foreign Union of Pharmacology (IUPHAR) was once demonstrated in 1994 in Montreal, Canada. The institution of the GI part acknowledges the overseas growth of gastrointestinal pharmacology, together with simple and human experiences.
The Gastrointestinal component of IUPHAR geared up the 1st symposium, Biochemical Pharmacology as an method of Gastrointestinal illnesses: from easy technological know-how to scientific Perspectives, on 10-12 October, 1995, in Pécs, Hungary.
the most subject matters were:
- Gastrointestinal secretory and excretory fuctions
- Gastrointestinal motility
- Biochemical-pharmacological mechanisms in neural and hormonal activities all in favour of GI services
- major general and pathological biochemical mechanisms in GI features
- GI mucosal damage and defense
- Molecular mechanisms of premalignant and malignant ailments in GI tract
- Use of remoted cells and mobilephone cultures in bioochemical-pharmacological experiences to technique GI illnesses.
The provided papers are released during this booklet.
Read or Download Biochemical Pharmacology as an Approach to Gastrointestinal Disorders: Basic Science to Clinical Perspectives (1996) PDF
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Extra resources for Biochemical Pharmacology as an Approach to Gastrointestinal Disorders: Basic Science to Clinical Perspectives (1996)
In the present study, the mucosal application of TC increased the luminal histamine levels, suggesting that the increase in acid secretion in the damaged stomach may be mediated by histamine. This contention is supported by the fact that the enhanced acid response was significantly mitigated not only by cimetidine but by FPL-52694 as well. It is also known that the mast cells in the gastrointestinal mucosa are opposed to substance P-containing sensory neurons [10,11]. : Stimulation Inhibition Stimulatory Pathway'?
12. Hakanson R, Chen D, Sundler F. The ECL cells. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract, 3rd edn. New York: Raven Press; 1994: 1171-84. 13. Chen D, Zhao C-M, Monstein H-J et al. A time table of rat stomach ECL cell responses to gastrin. , eds. Gastrointestinal Tract and Endocrine System. Falk Symposium 77. Dordrecht, Boston, London: Kluwer Academic Publishers; 1994: 178-85. 14. Hakanson R, Tielemans Y, Chen D, Andersson K, Mattsson H, Sundler F. Time-dependent changes in enterochromaffinlike cell kinetics in stomach of hypergastrinemic rats.
The present study addresses the questions of how histamine is stored in the EeL cells and how it is released upon stimulation with gastrin. cx-Fluoromethylhistidine (~ FMH) was given to the adult rats to deplete histamine from the EeL cells by inhibiting the histamineforming enzyme, histidine decarboxylase. Gastrin-17 infusion or omeprazole treatment was used to induce hypergastrinaemia. EeL cell profiles (electron micrographs) were analysed planimetrically. Based on ultrastructural observations, we characterized the secretory organelles in the EeL cells and classified them into granules (median profile diameter 120 nm), secretory vesicles (180 nm), microvesicles (70 nm), and vacuoles (more than 500 nm).
Biochemical Pharmacology as an Approach to Gastrointestinal Disorders: Basic Science to Clinical Perspectives (1996) by K. D. Rainsford (auth.), Timothy S. Gaginella, Gyula Mózsik, K. D. Rainsford (eds.)