Read e-book online Advances in Immunology, Vol. 40 PDF


By Frank J. Dixon, K. Frank Austen, Leroy E. Hood, Jonathan W. Uhr (Eds.)

ISBN-10: 0120224402

ISBN-13: 9780120224401

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1976) and that MC#I amplify PWM responsiveness (Rosenberg and Lipsky, 1979). Consistent with reports in the literature, the IgD- subset was greatly en- B LYMPHOCYTE ACTIVATION 25 TABLE V Ig ISOTYPE SECRETED BY PWM-STIMULATED [email protected]+ A N D IgD- B CELLS" PWM-stimulated Ig secretion (ng Ig secreted/ml) Experiment Population IgM IgG IgA 1 Control IgD+ IgDControl IgD+ IgD- 120 205 533 680 320 680 253 0 1333 248 0 1040 147 0 1333 1640 31 1700 2 a Control unsorted B cells and B cells sorted into fluorescence-positive and -negative subsets after reacting with antiIgD were cultured at 1 x 10Vwell with PWM and 50,000 mitomycin C-treated T cells/well and 5000 irradiated Md/ well.

As shown in Table XVII, T cell supernatant and r-IL-2 were able to support the differentiation of ISC from peripheral blood and spleen B cells comparably. By contrast, the number of Ig-secreting cells generated from lymph node B cells supported by r-IL-2 was only 10-15% as large as that supported by T cell supernatant. These results emphasize the importance of both the activating stimulus and the origin of the B cells in determining the lymphokine requirements of human B cell responsiveness. TABLE XVI EFFECTOF “BCGF” ON THE IL-2 RESPONSIVENESS OF ACTIVATEDB CELLS” 13H]Thymidineincorporation (cpm x 10-3) Stimulus B cell source Lymphokine Nil S.

1986a) demonstrated that responsiveness to T cell factors, SA + T cell factors, and PWM was still observed in the IgD- subset even following removal of the 4F2+ B cells (IgD- 4F2- subset). Data provided in this study indicate resting as well as activated IgD- B cells respond to T cell factors, PWM, and SA + T cell factors. B LYMPHOCYTE ACTIVATION 27 These studies have provided information regarding the response characteristics of resting virgin B cells and those of circulating memory cells. Findings obtained from these studies (summarized in Fig.

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Advances in Immunology, Vol. 40 by Frank J. Dixon, K. Frank Austen, Leroy E. Hood, Jonathan W. Uhr (Eds.)

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