Read e-book online Advances in Immunology, Vol. 40 PDF
By Frank J. Dixon, K. Frank Austen, Leroy E. Hood, Jonathan W. Uhr (Eds.)
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Additional resources for Advances in Immunology, Vol. 40
1976) and that MC#I amplify PWM responsiveness (Rosenberg and Lipsky, 1979). Consistent with reports in the literature, the IgD- subset was greatly en- B LYMPHOCYTE ACTIVATION 25 TABLE V Ig ISOTYPE SECRETED BY PWM-STIMULATED [email protected]+ A N D IgD- B CELLS" PWM-stimulated Ig secretion (ng Ig secreted/ml) Experiment Population IgM IgG IgA 1 Control IgD+ IgDControl IgD+ IgD- 120 205 533 680 320 680 253 0 1333 248 0 1040 147 0 1333 1640 31 1700 2 a Control unsorted B cells and B cells sorted into fluorescence-positive and -negative subsets after reacting with antiIgD were cultured at 1 x 10Vwell with PWM and 50,000 mitomycin C-treated T cells/well and 5000 irradiated Md/ well.
As shown in Table XVII, T cell supernatant and r-IL-2 were able to support the differentiation of ISC from peripheral blood and spleen B cells comparably. By contrast, the number of Ig-secreting cells generated from lymph node B cells supported by r-IL-2 was only 10-15% as large as that supported by T cell supernatant. These results emphasize the importance of both the activating stimulus and the origin of the B cells in determining the lymphokine requirements of human B cell responsiveness. TABLE XVI EFFECTOF “BCGF” ON THE IL-2 RESPONSIVENESS OF ACTIVATEDB CELLS” 13H]Thymidineincorporation (cpm x 10-3) Stimulus B cell source Lymphokine Nil S.
1986a) demonstrated that responsiveness to T cell factors, SA + T cell factors, and PWM was still observed in the IgD- subset even following removal of the 4F2+ B cells (IgD- 4F2- subset). Data provided in this study indicate resting as well as activated IgD- B cells respond to T cell factors, PWM, and SA + T cell factors. B LYMPHOCYTE ACTIVATION 27 These studies have provided information regarding the response characteristics of resting virgin B cells and those of circulating memory cells. Findings obtained from these studies (summarized in Fig.
Advances in Immunology, Vol. 40 by Frank J. Dixon, K. Frank Austen, Leroy E. Hood, Jonathan W. Uhr (Eds.)