Avram Hershko (auth.), Jan-Michael Peters, J. Robin Harris,'s Ubiquitin and the Biology of the Cell PDF


By Avram Hershko (auth.), Jan-Michael Peters, J. Robin Harris, Daniel Finley (eds.)

ISBN-10: 1489919228

ISBN-13: 9781489919229

ISBN-10: 1489919244

ISBN-13: 9781489919243

The final a number of years were a landmark interval within the ubiquitin box. The breadth of ubiquitin's roles in cellphone biology used to be first sketched, and the significance of ubiquitin-dependent proteolysis as a regulatory mechanism received normal reputation. the various strands of labor that ended in this new notion are re­ counted during this publication. A end result of this development is that the sector has grown dramatically because the first booklet on ubiquitin used to be released virtually a decade in the past [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. during this span, scholars of the cellphone cycle, transcription, sign transduction, protein sorting, neuropathology, melanoma, virology, and immunology have tried to chart the position of ubi surrender in of their specific experimental platforms, and this integration of the sector into mobile biology as a complete maintains at a outstanding speed. we are hoping that for lively researchers within the box in addition to for beginners and people at the fence, this booklet will end up worthy for its breadth, old standpoint, and useful advice. Structural facts are actually on hand on a few of the elements of the ubiquitin pathway. The constructions have supplied simple insights into the bizarre biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. simply because high-speed special effects can show buildings extra successfully than print media, we've supplemented the figures of the booklet with a global website which can reveal the constructions in a versatile, viewer-controlled format.

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Ubiquitin and the Biology of the Cell by Avram Hershko (auth.), Jan-Michael Peters, J. Robin Harris, Daniel Finley (eds.)

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