Toxicological profiles - White Phosphorus by Unknown PDF


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1 Key r m g t Rat Mouse Guinea Pig Goat LOAEL for serious effects (animals) LOAEL for less serious effects (animals) The number next to each point corresponds to entries in Table 2-1. NOAEL (animals) LOAEL for less serious effects (humans) Minimal risk level for effects other than cancer m op l ve e D 23r 23r 18r 100 al t en e tiv WHITE PHOSPHORUS 2. HEALTH EFFECTS Respiratory Effects White Phosphorus. In a study of 71 humans occupationally exposed to fumes/vapors and paste containing white phosphorus for intermediate or chronic duration, an irritating cough was reported as occurring in a large proportion of the employees (Ward 1928); no further information regarding respiratory effects was reported.

With one exception (Jakhi et al. 2), all reported cases of phossy jaw have resulted from occupational exposure to white phosphorus fumes/vapors and/or dust. Because white phosphorus oxidizes rapidly, phosphorus fumes/vapors may contain phosphoric oxide and phosphorus oxide, in addition to phosphorus (Heimann 1946; Hughes et al. 1962; Ward 1928). In a study of workers exposed to white phosphorus for intermediate durations in three fireworks plants, 2 of 44 workers developed definite cases of phossy jaw (Ward 1928).

Information on hepatotoxicity after exposure to airborne white phosphorus is limited to an occupational exposure study. No alterations in liver function tests were observed in workers chronically exposed to an unreported amount of airborne white phosphorus (Hughes et al. 1962). No studies were located regarding hepatic effects in animals after inhalation exposure to white phosphorus. White Phosphorus Smoke. No studies were located regarding hepatic effects in humans after inhalation exposure to white phosphorus smoke.

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Toxicological profiles - White Phosphorus by Unknown

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