Toxicological profiles - Naphthalene by Syracuse Research Corporation PDF


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Ocular Effects. Two case studies were reported in which humans experienced eye irritation and conjunctivitis as a result of naphthalene exposure (van der Hoeve 1906). In one case a worker accidentally got naphthalene powder in his left eye. The exact amount was unknown but described by the worker as large. Despite immediate cleansing of the eye, the subject experienced conjunctivitis and pain shortly after exposure. Symptoms of irritation subsided but then reappeared 6 weeks later. At that time the subject noticed decreased vision in his left eye.

Eight rabbits (strain not identified) all developed cataracts during oral administration of naphthalene at 2,000 mg/kg/day for 5 days (Srivastava and Nath 1969). Cataracts began to develop by the first day after a single 1,000 mg/kg naphthalene dose in 3 Chinchilla Bastard rabbits (Rossa and Pau 1988). In the solitary New Zealand white rabbit tested, cataracts began to develop after administration of four 1,000 mg/kg doses (dosing 2 times/week) and maximized after 12 weeks (Rossa and Pau 1988).

7 mg/kg/day 1-methylnaphthalene for 81 weeks (Murata et al. 1993). Hematological Effects. The most common hematologic effect in humans following the ingestion of naphthalene is hemolytic anemia (Dawson et al. 1958; Gidron and Leurer 1956; Gupta et al. 1979; Haggerty 1956; Kurz 1987; MacGregor 1954; Mackell et al. 1951; Melzer-Lange and Walsh-Kelly 1989; Ojwang et al. 1985; Shannon and Buchanan 1982). Changes observed in hematology and blood chemistry are consistent with this effect: hemolysis, decreased hemoglobin and hematocrit values, increased reticulocyte counts, serum bilirubin levels, and Heinz bodies.

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Toxicological profiles - Naphthalene by Syracuse Research Corporation

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