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The condition induced in these rats was referred to as "hepatic coma" (Zieve et al. 1974) because it was demonstrated in a previous study that injection of an ammonium salt or fatty acid into rats resulted in coma accompanied by massive hepatic necrosis. In the current study of synergism, Zieve et al. (1974), hepatic damage was assumed but not demonstrated, and it is not clear if methyl mercaptan exposure resulted in increased hepatic damage in these rats. These results suggest, however, that human exposure to methyl mercaptan in conjunction with hepatotoxins may result in exacerbated liver damage and/or neurotoxicity.

1 Data Needs Physical and Chemical Properties. The dissociation constant of methyl mercaptan in water is not known precisely (Reid et al. 1958; Yabroff 1940) and this measurement would be useful in predicting the environmental fate and transport of this compound. A laboratory verification of the estimated Henry's law constant for methyl mercaptan (Hassett et al. 1983) would provide a more accurate measurement of air-water partitioning. Production, Import/Export, Use, and Disposal. No data were located with regard to past or present production, use, release, or disposal of methyl mercaptan.

Reaction products underthese conditions include sulfur dioxide, nitric acid, formaldehyde, methylnitrate, methanesulfonic acid, inorganic sulfate (Grosjean 1984), dimethyldisulfide, and nitric oxide (Balla and Heicklen 1985). Reaction with the nitrate radical (NO3) may be the dominant atmospheric loss process for methyl mercaptan under certain conditions (Dlugokencky and Howard 1988; Mac Leod et al. 1986). The rate constant for the reaction of atmospheric methyl mercaptan with NO3 was recently determined (Dlugokencky and Howard 1988; Mac Leod et al.

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Toxicological profiles - Methyl mercaptan

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