Toxicological profiles - Jet fuels (jp4 and jp7) by Unknown PDF

Pharmacology

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Extra info for Toxicological profiles - Jet fuels (jp4 and jp7)

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No studies were located regarding hepatic effects in humans after dermal exposure to JP-4 or JP-7 or in animals after dermal exposure to JP-7. Application of 2,000 mg/kg shale-derived JP-4 to the skin of rabbits for 24 hours did not result in hepatic lesions after a 14-day postexposure period (Dennis 1982a). Renal Effects. No studies were located regarding renal effects in humans after dermal exposure to JP-4 or JP-7 or in animals after dermal exposure to JP-7. Dermal application of 2,000 mg/kg shale-derived JP-4 in five male and five female rabbits for 24 hours did not result in pathological renal effects related to the test material after a 14-day postexposure period (Dennis 1982a).

Mild progressive kidney neuropathies and medullary mineral deposits were observed in male, but not 3 female, rats exposed to 5,000 mg/m JP-4 for 12 months, 6 hours/day, 5 days/week (Bruner et al. 1993). Twelve months after the conclusion of the exposure period, medullary mineral deposits were 3 still present in the 5,000 mg/m group. Moreover, those changes were also seen in the kidneys of 3 rats exposed to 1,000 mg/m JP-4 (Bruner et al. 1993). Similar effects were observed in rats after 1 3 year of intermittent exposure to 150 or 750 mg/m JP-7 (Air Force 1991).

Hepatic inflammation was not 3 observed in the exposed males. A LOAEL of 150 mg/m was identified for hepatic inflammation in female mice. Renal Effects. No studies were located regarding renal effects in humans after inhalation exposure to JP-4 or JP-7. Blood urea nitrogen was elevated, but considered to be within normal limits, in Fischer 344 rats 3 exposed continuously (24 hours/day) for 90 days to 500 or 1,000 mg/m shale- or petroleum-derived JP-4 (Air Force 1980, 1984c). In a subsequent 1-year study using an intermittent exposure protocol 3 (6 hours/day, 5 days/week) and a higher concentration of JP-4 (5,000 mg/m ), blood urea nitrogen was increased only in female rats (Air Force 1981i).

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Toxicological profiles - Jet fuels (jp4 and jp7) by Unknown


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