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1981, 1990; Hardell et al. 1981). In a retrospective cohort study on Danish workers exposed to 2,4-DCP and 4-chloro-o-tolyloxyacetic acid (MCPA), there was an elevated risk of STS supporting the Swedish findings but no excess of malignant lymphomas or the total number of cancers (Lynge 1985). Because considerable public controversy arose during the Swedish investigations, as opposed to other investigations, the Swedish studies may have been subject to considerable recall bias and lack of control for confounding variables (Bond et al.

A cancer mortality study (2,377 deaths among a population of 18,910) of sprayers and production workers exposed to chlorophenoxy herbicides and chlorophenols found a nonsignificant increase in soft tissue sarcoma, which was based on four deaths (Saracci et al. 1991). Risk for cancers of the testes, thyroid, other endocrine glands and the nose and nasal cavity also increased by more than twofold. A large population exposed exclusively to chlorophenols could not be identified. The investigators (Saracci et al.

6 Developmental Effects No studies were located regarding developmental health effects in humans or animals after inhalation exposure to any of the eight chlorophenols discussed in this profile. 5. CHLOROPHENOLS 2. 8 Cancer A number of investigators have studied the potential association between chlorophenol-based pesticide production and carcinogenicity (Eriksson et al. 1981, 1990; Hardell et al. 1981; Hoar et al. 1986; Honchar and Halperin 1981; Kogevinas et al. 1992; Lynge 1985; Smith et al.

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Toxicological profiles - Chlorophenols by Unknown

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