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This corresponds to a half-life of more than 1,000 years. Biodegradation in aqueous media may be significant in some cases. For example, Tabak et al. (1981) reported 35% transformation after seven days incubation in a medium inoculated with sewage. Repeated culturing lead to increased losses, indicating gradual adaptation of the degradative microbes. 5. POTENTIAL FOR HUMAN EXPOSURE Under aquatic conditions where volatilization cannot occur, biodegradation may be the predominant mechanism for degradation of BDCM.

1982). These doses are not significantly different from those observed to cause hepatic injury in acute and short-term studies, suggesting that there is a relatively low tendency toward cumulative injury to liver. An exception is the study of Chu et al. (1982b), where statistically significant effects on liver were noted in rats exposed to doses as low as 7 mg/kg/day for 90 days. However, these effects were minimal (the authors assigned a severity score of 2 on a scale of 1 to 10) and showed essentially no dose-response tendency.

2% in mice, and 2% to 6% in monkeys) (Mink et al. 1986; Smith et al. 1985). Fecal excretion in monkeys accounted for less than 2% of the administered dose 72 hours after dosing (Smith et al. 1985). In rats, Smith et al. (1985) found no detectable amounts of radiolabelled BDCM or metabolites in the feces, but the feces were evaluated only up to 6 hours after administration of BDCM. The shortness of the time interval does not give an accurate assessment of the feces as a route of excretion for BDCM, since 37% of the administered dose in the rats was accounted for in the gastrointestinal tract.

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Toxicological profiles - Bromodichloromethane

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