New PDF release: Toxicological profiles - Atrazine


Read or Download Toxicological profiles - Atrazine PDF

Best pharmacology books

Download PDF by Stephanie T. Weiss: High-Yield Pharmacology (3rd Edition) (High-Yield Series)

Now in its 3rd variation, High-Yield™ Pharmacology offers a succinct evaluate of pharmacology whereas clarifying tough ideas. Need-to-know info is gifted in a transparent, concise define structure. extra positive factors comprise up-to-date drug references, a drug index, key issues in daring, and tables summarizing key proof.

Download e-book for iPad: In Silico Methods for Predicting Drug Toxicity by Emilio Benfenati

This particular quantity explores in silico equipment for pharmaceutical toxicity by means of combining the theoretical complex learn with the sensible program of the instruments. starting with a piece masking subtle versions addressing the binding to receptors, pharmacokinetics and adsorption, metabolism, distribution, and excretion, the ebook keeps with chapters delving into versions for particular toxicological and ecotoxicological endpoints, in addition to wide perspectives of the most projects and new views so that it will in all likelihood increase our method of modelling prescription drugs.

Additional resources for Toxicological profiles - Atrazine

Sample text

Levels of Significant Exposure to Atrazine a Key to figure 41 Exposure/ Duration/ Frequency Species (Strain) (Specific Route) Rat (SpragueDawley) 42 Rat (LongEvans) 0 > n 0 C System 21d 1 x/d (GW) Bd Wt 21d Endocr 1x/d ( GW) 43 Rat (SpragueDawley) 21d 44 Rat CFY 3mo (F) 1x/d (GW) Bd Wt NOAEL (mg/kg/day) Less Serious (mg/kg/day) 300 75 150 300 W r n O z Hemato 75 Hepatic 75 Renal Bd Wt 45 Rat (SpragueDawley) 14-23d 1x/d Endocr 38 Serious ( mg/kg/day) Reference Chemical Form Cooper et al. 1996 (decreased serum LH; i ncreased pituitary prolactin) Cooper et al.

Acute respiratory distress or death). "Less serious" effects are those that are not expected to cause significant dysfunction or death, or those whose significance to the organism is not entirely clear. ATSDR acknowledges that a considerable amount of judgment may be required in establishing whether an end point should be classified as a NOAEL, "less serious" LOAEL, or "serious" LOAEL, and that in some cases, there will be insufficient data to decide whether the effect is indicative of significant dysfunction.

The significance of the exposure levels shown in the Levels of Significant Exposure (LSE) tables and figures may differ depending on the user's perspective. Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. Estimates of levels posing minimal risk to humans (Minimal Risk Levels or MRLs) may be of interest to health professionals and citizens alike.

Download PDF sample

Toxicological profiles - Atrazine

by John

Rated 4.78 of 5 – based on 22 votes