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Additional info for Toxicological profiles - Acrylonitrile

Example text

Because only six cases of prostate cancer were observed and all were found in workers at ages when the incidence rate increases, firm conclusions cannot be made about the potential for acrylonitrile to cause prostate cancer. In animals, acrylonitrile has been demonstrated to cause tumors at multiple sites, including the nervous system, gastrointestinal tract, Zymbal gland and mammary gland. Because of this clear carcinogenic potential, chronic low-level exposure to acrylonitrile is of special concern.

However, the liver has not been indicated as a target organ for intermediate or chronic exposure in humans or animals. In factory workers exposed to acrylonitrile for 10 or more years, no liver damage has been observed (Sakurai et al. 1978). In animal studies, microscopic examination of liver tissue has revealed no hepatic damage after 90 days to 2 years of exposure by the inhalation or oral routes (Bio/dynamics 1980a, 1980b, 1980c; Humiston et al. 1975; Quast 1975, 1980a, 1980b). Some effects seen in the livers of animals may suggest that adaptive changes occur as a response to increased metabolic activity.

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'  2 2. 4 mg acrylonitrile/kg body weight/day (mg/kg/day) or higher may result in premature death (Bio/dynamics 1980a, 1980b, 1980c; Gallagher et al. 1988; Quast et al. 1980b). The cause of death was not specifically identified.

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Toxicological profiles - Acrylonitrile

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