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Additional info for Toxicological profiles - 4,4'-methylenebis-(2-chloroaniline) (mboca)

Sample text

He washed his face and eyes immediately after the incident. No further information was given about his condition. As with other occupational exposure studies, there was no information on the dose to which he was exposed. Another limitation of this study is the likelihood that some of the MBOCA was inhaled or ingested. No information was located regarding gastrointestinal effecting in animals after dermal exposure to MBOCA. Renal Effects. In a retrospective bladder cancer incidence study conducted among 532 worke exposed to MBOCA from 1968 to 1979 and 20 workers who were first employed in 1980 and 1980, 385 participated in the urine screening test (Ward et al.

Exfoliative cytology revealed thal 21 urine samples contained atypical cells. No cytology readings were positive for cancer. Sixtcen urine samples were positive for heme (Ward et al. 1990). 2 months. This study is important because it gathered information on a relatively large group of workers exposed to MBOCA and alerted medical professionals to the limitations of follow-up procedures used after MBOCA exposure. In the course of the screening, one of the participants who had negative cytology and was negative for the presence of heme in the urine was diagnosed with a tumor of the urinary bladder.

After inhalation of low levels, excretion of MBOCA has been monitored by measuring the amount in urine. Excretion occurs rapidly during the first 48 hours (NIOSH 1986a). 34 L of molten MBOCA, 1,700 ppb of MBOCA was found in the worker’s urine four hours later (NIOSH 1986a; Osorio et al. 1990). This result suggests the rapid excretion of MBOCA after acute dermal and/or inhalation exposure. It is not clear, however, if urine is indeed the primary route of excretion in humans, since no information was presented on the amount of MBOCA contained in the feces.

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