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Additional info for Toxicological profiles - 2,3-benzofuran

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No data exist on the health effects of 2,3-benzofuran in animals following inhalation or dermal exposure. Information on the health effects in rats and mice following oral exposure to 2,3-benzofuran comes primarily from a wellconducted gavage study by NTP of acute-, intermediate-, and chronic-duration (NTP 1989). However, this NTP study was limited to examining histopathological endpoints, so information on immunologic, neurologic and reproductive effects does not include evidence concerning organ or system function.

Absorption, Distribution, Metabolism, and Excretion. No data are available on the absorption, distribution, metabolism, or excretion of 2,3-benzofuran in humans. Limited data suggest the involvement of P-450 oxygenases in the metabolism of 2,3-benzofuran in animals (Heine et al. 1986; McMurtry and Mitchell 1977), and further investigations would be valuable to define the role of organ-specific oxygenases in the toxicity and potential genotoxicity of 2,3-benzofuran. Absorption, distribution, and excretion in animals have not been studied at all via inhalation, oral, or dermal routes.

Although 2,3-benzofuran is a component of coumarone-indene resin and this resin has been approved by the FDA for use as a coating on citrus fruits, as a component of food-preparation utensils, and as an adhesive in food packages (see Table 7-1), no information was located confirming that coumarone-indene resin is currently used on food in the United States. Furthermore, no data were located to indicate that 2,3-benzofuran migrates from the resin into foodstuffs. 5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE Humans may be exposed to 2,3-benzofuran by inhalation, ingestion, or dermal absorption.

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Toxicological profiles - 2,3-benzofuran

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