Read Online or Download Toxicological profiles - 2,3-benzofuran PDF

Similar pharmacology books

Download e-book for iPad: High-Yield Pharmacology (3rd Edition) (High-Yield Series) by Stephanie T. Weiss

Now in its 3rd variation, High-Yield™ Pharmacology offers a succinct evaluate of pharmacology whereas clarifying tricky suggestions. Need-to-know info is gifted in a transparent, concise define structure. extra beneficial properties contain up-to-date drug references, a drug index, key issues in daring, and tables summarizing key proof.

Download e-book for iPad: Toxicological profiles - Antimony and compounds by

Download e-book for iPad: Developing An Integrated Drug Information System: Global by United Nations

Emilio Benfenati's In Silico Methods for Predicting Drug Toxicity PDF

This exact quantity explores in silico tools for pharmaceutical toxicity by means of combining the theoretical complicated learn with the sensible software of the instruments. starting with a piece overlaying refined versions addressing the binding to receptors, pharmacokinetics and adsorption, metabolism, distribution, and excretion, the publication maintains with chapters delving into types for particular toxicological and ecotoxicological endpoints, in addition to large perspectives of the most tasks and new views to be able to in all probability increase our approach of modelling prescribed drugs.

• Methaqualone: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References
• Rökan: Ginkgo biloba / Recent Results in Pharmacology and Clinic
• Antibiotic Pharmacodynamics
• Philosophy of Psychopharmacology
• The Benzodiazepines: Current Standards for Medical Practice
• Fundamentals of biochemical pharmacology

Additional info for Toxicological profiles - 2,3-benzofuran

Example text

No data exist on the health effects of 2,3-benzofuran in animals following inhalation or dermal exposure. Information on the health effects in rats and mice following oral exposure to 2,3-benzofuran comes primarily from a wellconducted gavage study by NTP of acute-, intermediate-, and chronic-duration (NTP 1989). However, this NTP study was limited to examining histopathological endpoints, so information on immunologic, neurologic and reproductive effects does not include evidence concerning organ or system function.

Absorption, Distribution, Metabolism, and Excretion. No data are available on the absorption, distribution, metabolism, or excretion of 2,3-benzofuran in humans. Limited data suggest the involvement of P-450 oxygenases in the metabolism of 2,3-benzofuran in animals (Heine et al. 1986; McMurtry and Mitchell 1977), and further investigations would be valuable to define the role of organ-specific oxygenases in the toxicity and potential genotoxicity of 2,3-benzofuran. Absorption, distribution, and excretion in animals have not been studied at all via inhalation, oral, or dermal routes.

Although 2,3-benzofuran is a component of coumarone-indene resin and this resin has been approved by the FDA for use as a coating on citrus fruits, as a component of food-preparation utensils, and as an adhesive in food packages (see Table 7-1), no information was located confirming that coumarone-indene resin is currently used on food in the United States. Furthermore, no data were located to indicate that 2,3-benzofuran migrates from the resin into foodstuffs. 5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE Humans may be exposed to 2,3-benzofuran by inhalation, ingestion, or dermal absorption.

Download PDF sample