New PDF release: Successful Drug Discovery, Volume 2
By Janos Fischer, Wayne E. Childers
Protecting the profitable strategy present in the former quantity during this sequence, the inventors and first builders of substances that effectively made it to marketplace inform the tale of the drug's discovery and improvement and relate the usually twisted course from the 1st candidate molecule to the ultimate advertised drug.
eleven chosen case reviews describe lately brought medications that experience now not been formerly lined in textbooks or basic references. those diversity throughout six diversified healing fields and supply a consultant cross-section of the present drug improvement efforts. subsidized by means of copious facts and chemical info, the perception and event of the participants makes this some of the most helpful education manuals junior medicinal chemist can desire to discover and has gained the help and endorsement of IUPAC.
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Additional info for Successful Drug Discovery, Volume 2
Ganesan, A. (2014) Macrocyclic inhibitors of zinc-dependent histone deacetylases (HDACs), in Macrocycles in Drug Discovery, (ed. J. Levin), RSC, Cambridge, pp. 109–140. P. E. (2002) Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms. Clinical Cancer Research, 8, 718–728. , Altemus, R. E. (2001) Inhibitor of References 17 18 19 20 21 22 histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report.
2014) Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity. European Journal of Medicinal Chemistry, 76, 301–313. , Sasahara, K. and Doi, T. (2015) Total synthesis of cyclodepsipeptide spiruchostatin A on silyllinked polymer-support. Tetrahedron, 71, 7647–7653. 2 Romidepsin and the Zinc-Binding Thiol Family of Natural Product HDAC Inhibitors A. Ganesan did his undergraduate studies in Chemistry at the National University of Singapore followed by a PhD supervised by Clayton H.
And Doi, T. (2011) Total synthesis of spiruchostatin B aided by an automated synthesizer. Organic & Biomolecular Chemistry, 9, 3825–3833. , Xu, Z. and Ye, T. (2012) Total synthesis and stereochemical revision of burkholdac A. Synlett, 23, 783–787. , Yoshida, M. and Katoh, T. (2013) Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities. European Journal of Medicinal Chemistry, 60, 295–304. , Yoshida, M.
Successful Drug Discovery, Volume 2 by Janos Fischer, Wayne E. Childers