Download PDF by Raymond F. Burk (auth.), Raymond F. Burk (eds.): Selenium in Biology and Human Health


By Raymond F. Burk (auth.), Raymond F. Burk (eds.)

ISBN-10: 1461225922

ISBN-13: 9781461225928

ISBN-10: 1461275970

ISBN-13: 9781461275978

Selenium performs a desirable and nonetheless poorly understood position within the functionality of dwelling cells and consequently in human overall healthiness. beginning with investigations over 60 years in the past into its position as a poisonous agent in cattle ailment, selenium reviews have improved quickly with the appliance of instruments from immunology and molecular biology. Selenium is referred to now to be vital in human and animal meals, has been chanced on as a structural component to so-called selenoproteins, and should play a couple of physiological roles, starting from melanoma security to hormone metabolism. Selenium in Biology and Human Health provides learn syntheses on a number of themes concerning selenium, written through experts from all over the world. will probably be of curiosity to cellphone biologists and physiologists, dietary scientists, and animal health and wellbeing researchers.

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Leinfelder, W, Forchhammer, K, Veprek, B, Zehelein, E, Bock, A. In vitro synthesis of selenocysteinyl-tRNAucA from seryl-tRNA ucA : involvement and characterization of the selD gene product. Proc Natl Acad Sci USA 87:543-547; 1990. Maenpaa, PH, Bernfield, MR. A specific hepatic transfer RNA for phosphoserine. Proc Natl Acad Sci USA 67:688-695; 1970. Margulis, L, Schwartz, KV. Five Kingdoms, an Illustrated Guide to the Phyla of Life on Earth 2nd ed. San Francisco, WH Freeman; 1988. 2. Selenocysteine tRNA[SerjSec Isoacceptors 43 Marshall, R, Caskey, T, Nirenberg, M.

1991 (20) Criqui et aI. 1992 (19) 190/39 190/40 Androgen-related epididymal secretory protein 175*/27 Mouse Epididymis cDNA 221/73 Rat Epididymis eDNA Monkey Epididymis eDNA 221/73 GPX-like proteins S. mansoni Tobacco Protoplast eDNA eDNA 169*/43 169/43 1 Polypeptide length/[Se]Cys position from N-terminal end. including the start ATG, and thus the polypeptide is not full length. * Clone is missing some of the 5' -coding region, mansoni with 38% amino acid sequence identity with human GPX (20).

Selenocysteine tRNAlSerjSec Isoacceptors 27 INTRODUCTION In recent years, a variety of experimental results have led to the surprising conclusion that under certain circumstances the UCA termination codon signals the translational insertion of selenocysteine into protein. , 1984]) occurs in the open reading frame of genes for formate dehydrogenase in E. , 1988) and (2) a selenocysteyl-tRNA that decodes UCA occurs in E. , 1989b). The genes that utilize UCA for selenocysteine (for review see Stadtman, 1991) and the tRNAs that serve as carrier molecules for the biosynthesis of selenocysteine and donate selenocysteine to protein have been observed in a wide variety of organisms as described below.

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Selenium in Biology and Human Health by Raymond F. Burk (auth.), Raymond F. Burk (eds.)

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