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By Hirosi Kuriyama (auth.), Robert S. Moreland (eds.)
Sixth Annual Graduate health center examine Symposium rules OF delicate MUSCLE development IN fixing THE PUZZLE from time to time a systematic convention comes at a time while each person has new and interesting info, while outdated "dogmas" don't appear to be besides confirmed, and while audio system and individuals alike are able to problem interpretations of previous and new experimental information. This used to be this kind of convention. What activates a soft muscle cellphone? the appropriate solution to this question has eluded scientists much longer than i've been taken with the sector. we all know that a rise in cytosolic calcium is critical and we all know that phosphorylation of the 20 kDa myosin mild chain is a vital step within the method. we don't understand if different methods are worthwhile for the initiation and lor upkeep of a tender muscle contraction nor will we be aware of if different approaches modulate the law of contraction. The target of the symposium on which this quantity relies used to be to discover the most up-tp-date hypotheses for the solutions to those questions. i feel that once studying the chapters integrated during this quantity, you are going to agree that this objective used to be accomplished. the significance of calcium and calmodulin based myosin gentle chain phosphoryla tion within the legislation of delicate muscle contraction was once strengthened by way of many shows. even if, the prestige of myosin mild chain phosphorylation as an easy calcium based change got here less than critical suspicion.
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Additional info for Regulation of Smooth Muscle Contraction
Of Ca 2+. B: selected reaction mixtures from A were analyzed by SDS-PAGE and autoradiography. M calponin (+Ca 2+ + calponin). 40 0·8 0·6 ~0·4 « 0·2 2 4 6 10 8 TIME (min) 12 14 Figure 3. Inhibition of actomyosin superprecipitation by calponin. Super-precipitation of actomyosin was measured by an increase in A660nm in the fully reconstituted system (see legend to Fig. 2) in the presence of Ca 2+ and in the presence (0) and absence (e) of 5 ~ calponin. Non-radiolabeled ATP (1 mM) was added to the reaction mixtures at time zero.
1984, Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase, J. Bioi. , 259: 8808. , 1986, The essential light chains constitute part of the active site of smooth muscle myosin, Nature, 324: 78. Onishi, H. , 1982, Electron microscopic studies of myosin molecules from chicken gizzard muscle I: The formation of the intramolecular loop in the myosin tail, J. , 92: 871. Onishi, H. , 1984, Correlation between the papain digestibility and the conformation of lOS-myosin from chicken gizzard, J.
87: 414. , Blumenthal, D. , Walsh, K. A, Krebs, E. , 1985, Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase, Biochemistry, 24: 6028. , Blumenthal, D. , Walsh, K. , and Krebs, E. , 1986, Amino acid sequence of rabbit skeletal muscle myosin light chain kinase, Biochemistry, 25: 8049. Tan, J. L. and Spudich, J. , 1990, Dictyostelium myosin light chain kinase, J. Bioi. , 265: 13818. 24 REGULATION OF SMOOTH MUSCLE ACTOMYOSIN FUNCTION Mitsuo Ikebe, Toshiaki Mitsui, and Shinsaku Maruta Department of Physiology and Biophysics Case Western Reserve University School of Medicine Cleveland,OH 44106 INTRODUCTION It is widely accepted that the smooth muscle contractile apparatus is primarily regulated by reversible phosphorylation and dephosphorylation of the 20 kDa light chain of myosin (Hartshorne, 1987).
Regulation of Smooth Muscle Contraction by Hirosi Kuriyama (auth.), Robert S. Moreland (eds.)