Download PDF by A. Locker (auth.), A. Locker (eds.): Quantitative Biology of Metabolism: Models of Metabolism,


By A. Locker (auth.), A. Locker (eds.)

ISBN-10: 3540043012

ISBN-13: 9783540043010

ISBN-10: 3642510655

ISBN-13: 9783642510656

The improvement of the lifestyles sciences could be stated to have effected a steady transition from a roughly intuitive prescientific process in response to crude remark, through a extra sophisticated kind of commentary to experimentation and for that reason to the extent of formal theories. Quantitative equipment are brought on the moment point; they include: (a) quantitative layout of experiments; (b) regrouping of experimental effects; (c) evalua­ tion of effects by way of mathematical or particular statistical ideas. The final step implies the creation of theoretical ideas, yet we aren't justified in talking of theoretical technological know-how until actual theoretical con­ siderations-models or hypotheses-precede test, and this can be then by way of an try and hyperlink effects with conception in order to be certain the idea. Biology at this time turns out to lie someplace among the second one and 3rd point pointed out above, no longer but having completed the prestige of a theoretical technological know-how in all its branches. hence, notwithstanding the necessity for quantification and mathematical formula is widely known, many biologists nonetheless think that e.g. normal structures conception is just too summary to be of use in dealing with concrete difficulties. these, notwithstanding, who glance seriously at the moment scenario can't undertake this attitude.

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Additional info for Quantitative Biology of Metabolism: Models of Metabolism, Metabolic Parameters, Damage to Metabolism, Metabolic Control

Example text

The classical genetic block) usually leads to elimination of the measured property and sometimes to the elimination of the whole organism. This kind of experiment therefore yields mainly structural information and gives no quantitative answers as to the role of the enzyme. (Fig. 6a). There is, however, a related experiment which immediately gives quantitative information. ) as we may choose. g. introduce into an organism a mutant enzyme with altered activity (as in the strains in Fig. 5) or we could alter the quantity of enzyme by controlling the nuclear dose, or we could inhibit it in some specific manner.

Application of our Method to Cell Division Our mathematical method can effectively be applied to some biological problems like development, cytodifferentiation, etc. During cell cycle some metabolites regulating mitosis or DNA duplication must fluctuate. GOODWIN [1] transferred the ecological relation of prey-predator to oscillating metabolites. For this purpose, at least two kinds of metabolites, instead of one, are required. Let x and u be the metabolites regulating mitosis and DNA replication respectively, thenY and v of the following kinetic equations may correspond to the predator.

An enzyme, having undergone no change is nevertheless seen to have altered its role. Although by no means restricted to biological systems, it is in organisms that these concepts are essential to our understanding. 22 H. KAesER, and J. A. ). The well-known enzyme equations, established by enzymology, together with the structural information of our metabolic maps enables us to write down the set of equations in their differential form which represent the whole system. These will solve for us the questions for which we had no simple logical answer.

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Quantitative Biology of Metabolism: Models of Metabolism, Metabolic Parameters, Damage to Metabolism, Metabolic Control by A. Locker (auth.), A. Locker (eds.)

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