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Additional resources for Protein-Protein Interactions

Example text

Secondary hot spots are at positions of isobutyric acid and chlorophenyl group of second inhibitor molecule. Conformationally mobile binding pocket residues are highlighted (pdb 1r6n) improved by the presence of the first inhibitor molecule, and the two inhibitor molecules make excellent p–p interactions with their aromatic groups above the isobutyric acid. Nevertheless, accessing the two small subsites flanking the deep indanedione pocket could prove a source of additional or alternate binding energy.

6 mM, and no subsequent optimization work was reported. This compound is clearly far from being a drug, and is already quite large, though it is possible that improved potency could be attained. Nevertheless, SPD304 is very interesting in that it is able to disrupt a very strong, obligate proteinprotein interaction. Several other small-molecule modulators of PPIs operate on structural proteins, including a number of targets belonging to the antiviral field, specifically HIV-1, hepatitis C virus (HCV) and respiratory syncytial virus (RSV).

Several small-molecule peptide inhibitors have been reported, with affinities in the micromolar range, commensurate with measurements of native interactions [228]. Bivalent inhibitors recognizing dimeric or oligomeric PDZ domains in some proteins, and conformationally restricted peptidomimetics have also been described. A few groups have also reported small-molecule inhibitors of various PDZ domains [234]. The dishevelled (Dvl) proteins have attracted interest in recent years as a possible site of intervention into the Wnt signaling pathway, which has been shown to play a role in the development of some cancers.

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