Welling P.G.'s Pharmacokinetics: Regulatory - Industrial - Academic PDF


By Welling P.G.

ISBN-10: 0824793781

ISBN-13: 9780824793784

Delivering a different, multidisciplinary process, this state of the art moment version information the speedily altering position that medical and non-clinical pharmacokinetics and drug metabolism play within the discovery and improvement of drug therapies-emphasizing frequently ignored regulatory, medical, and financial matters.

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1977). Liver, kidney, adrenal, genital, and lung pathologies were monitored and compared with controls. It was noted that this exposure resulted in increased liver/body weight ratios, and granulation and vacuolization in liver cells. Cellular changes regressed after 19 exposures and were no longer observed following the 39th exposure. " No significant changes were noted in the other tissues monitored. The major limitation of this study was that only one dose (130 ppm) was examined. However, there were no intermediate-duration inhalation studies with dose-response data that could be used to derive an MRL.

1964; Jeney et al. 1957; Minot and Smith 1921) and inhalation exposure to rats and monkeys (Horiuchi et al. 1962; Schmidt et al. 1972). However, these studies are quite limited due to their age and other factors, and thus the data are inconclusive as to whether 1,1,2,2-tetrachloroethane will cause hematological effects in humans. Musculoskeletal Effects. No studies were found on musculoskeletal effects of 1,1,2,2-tetrachloroethane administered by the inhalation, oral, or dermal routes in humans or animals.

1969). Systemic Effects. Respiratory Effects. When administered by the inhalation or oral route, 1,1,2,2-tetrachloroethane has pronounced effects on the respiratory system, including irritation of the mucous membranes. Respiratory effects in humans have occurred only after exposures to what must have been very high concentrations of 1,1,2,2-tetrachloroethane (Mant 1953; Sherman 1953; Ward 1955). Present-day exposure standards preclude unintentional exposures to these levels of the chemical by humans, but accidental spills are still possible.

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Pharmacokinetics: Regulatory - Industrial - Academic Perspectives by Welling P.G.

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