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Extra info for Pharmacogenomics in Admixed Populations

Sample text

Therefore, population stratification is important in pharmacogenetics, since different types of variables could confound or modify the studied association. When it is possible to identify the stratification variable, combining different contingency tables or stratified analysis could clarify the roles of confounders and modifiers. However, a problem could occur when several confounders or modifiers are potentially present. In this case, the most common solution is to apply multivariate analyses such as regression models, to adjust the overall OR for the independent effect of the confounding variables.

If this is the case, adjusting the overall OR for the stratification variable is not appropriate, since the crude OR represents the average association between the APOE alleles and the drug-response variable, but it does not take into account the information concerning the different effects observed by the stratification variable across the strata. When the stratification variable modifies the studied association, a stratified analysis is suggested. Controlling the Effects of Population Stratification by Admixture in Pharmacogenetics 19 c.

In Mexico, intermixture of Spanish men with Indigenous American women began soon after the arrival of Hernán Cortés in 1521 and continued through the three centuries of Spanish domination in “New Spain”, configuring the Mexican population both biologically and culturally. Today, the majority of Mexicans (approximately 60% of the total population of more than 100 million people) are “mestizos”, a term used to describe persons of mixed European/Native American ancestry. It is important to mention that there was also a substantial African presence in Mexico during the Spanish rule.

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