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Extra resources for Pediatric Lymphomas (Pediatric Oncology)

Sample text

J Exp Med 198:851–862 Sahin U, Neumann F, Tureci O, et al (2002) Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/ restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and ReedSternberg cells. Blood 100:4139–4145 Saletti P, Ghielmini M, Scali G, et al (1999) Hodgkin’s and Castleman’s disease in a patient with systemic mastocytosis. Ann Hematol 78:97–100 Savage KJ, Monti S, Kutok JL, et al (2003) The molecular signature of Mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

49 . . 51 . . 51 . . . . . . . . 53 54 56 58 59 . . . . . . . . . 59 59 59 61 61 61 Treatment for children and adolescents with Hodgkin lymphoma (HL) aims to achieve cure without longterm morbidity. Earlier treatment approaches did not consider the developmental issues in pediatric patients that resulted in unacceptable musculoskeletal hypoplasia, cardiovascular and pulmonary dysfunction, and the development of subsequent primary cancers. Recognition of these life-altering and life-threatening late treatment effects motivated the development of combined-modality therapy regimens in which cycles of chemotherapy replaced a portion of the radiation therapy in laparotomy-staged children.

Many lymphoid neoplasms may contain cells resembling HRS cells, though characteristics of the primary disorder usually dominate. Infectious mononucleosis is a common mimic of CHL. These infectious lymphadenopathies are most often due to EBV, but other viruses, particularly cytomegalovirus, are also implicated. The clinical findings show cervical (often posterior cervical) lymphadenopathy with pharyngitis, malaise, low-grade fever, and often splenomegaly. The monospot test is positive, and there are rising titers of IgG and IgM viral capsid antibodies (Hess 2004).

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