Download e-book for iPad: Oocyte Biology in Fertility Preservation by S. Samuel Kim M.D., F.A.C.O.G. (auth.), S. Samuel Kim (eds.)


By S. Samuel Kim M.D., F.A.C.O.G. (auth.), S. Samuel Kim (eds.)

ISBN-10: 1461482135

ISBN-13: 9781461482130

ISBN-10: 1461482143

ISBN-13: 9781461482147

​Fertility upkeep has develop into probably the most vital and quickly growing to be fields of reproductive drugs. even though there are numerous techniques for fertility renovation in lady, such a lot of them are nonetheless thought of experimental. you will need to ideal the present applied sciences, but additionally constructing new techniques might be actively sought. the longer term improvement of fertility maintenance suggestions could be in response to the sound clinical wisdom and ideas. one of many major targets of fertility maintenance in ladies is prevention of oocyte depletion. The mechanisms of oocyte loss and survival within the ovary are complicated, which come with genetic keep watch over either in germ cells and in somatic cells, DNA harm and service mechanism, apoptosis and autophagy, and different poorly understood molecular mechanisms. To strengthen clinically potent and secure recommendations for fertility renovation, it truly is necessary to be aware of and comprehend the basics of oocyte and ovarian biology on the molecular point. hence, the aim of this version is to check the present growth in learn on the topic of molecular and genetic keep watch over of oocyte improvement that may be utilized to fertility upkeep. the most themes which are mentioned during this book contain molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.​

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2002), bone morphogenic protein 7 (BMP-7) (Lee et al. 2001, 2004), BMP-4 (Nilsson and Skinner 2003), and growth differentiation factor 9 (GDF-9) (Hreinsson et al. 2002; Martins et al. 2008; Vitt et al. 2000) enhance the activation of primordial follicles in vitro. Similarly, Smad3 (Tomic et al. 2004) and growth hormone (Slot et al. 2006) also enhance follicular activation in mice In Vitro Activation of Dormant Follicles Organ or Cortical Strip Culture The initial activation and the sustained in vitro growth of the most abundant dormant follicles are crucial to maximizing the reproductive potential of cryopreserved or fresh ovarian tissue.

Hum Reprod 23:699–708 Hirshfield AN (1991) Development of follicles in the mammalian ovary. Int Rev Cytol 124:43–101 Hornick JE, Duncan FE, Shea LD, Woodruff TK (2012) Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro. Hum Reprod 27(6):1801–1810 Hovatta O (2004) Cryopreservation and culture of human ovarian cortical tissue containing early follicles. Eur J Obstet Gynecol Reprod Biol 113(Suppl 1):S50–S54 Hreinsson JG, Scott JE, Rasmussen C, Swahn ML, Hsueh AJ, Hovatta O (2002) Growth differentiation factor-9 promotes the growth, development, and survival of human ovarian follicles in organ culture.

Mol Reprod Dev 25(4):374–383 Meirow D (2000) Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol 169(1–2):123–131 Moir RD, Spann TP, Herrmann H et al (2000) Disruption of nuclear lamin organization blocks the elongation phase of DNA replication. J Cell Biol 149(6):1179–1192 Santos F, Hendrich B, Reik W et al (2002) Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol 241(1):172–182 Stephens PJ, Greenman CD, Fu B et al (2011) Massive genomic rearrangement acquired in a single catastrophic event during cancer development.

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Oocyte Biology in Fertility Preservation by S. Samuel Kim M.D., F.A.C.O.G. (auth.), S. Samuel Kim (eds.)

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