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By S. Samuel Kim M.D., F.A.C.O.G. (auth.), S. Samuel Kim (eds.)
Fertility upkeep has develop into probably the most vital and quickly growing to be fields of reproductive drugs. even though there are numerous techniques for fertility renovation in lady, such a lot of them are nonetheless thought of experimental. you will need to ideal the present applied sciences, but additionally constructing new techniques might be actively sought. the longer term improvement of fertility maintenance suggestions could be in response to the sound clinical wisdom and ideas. one of many major targets of fertility maintenance in ladies is prevention of oocyte depletion. The mechanisms of oocyte loss and survival within the ovary are complicated, which come with genetic keep watch over either in germ cells and in somatic cells, DNA harm and service mechanism, apoptosis and autophagy, and different poorly understood molecular mechanisms. To strengthen clinically potent and secure recommendations for fertility renovation, it truly is necessary to be aware of and comprehend the basics of oocyte and ovarian biology on the molecular point. hence, the aim of this version is to check the present growth in learn on the topic of molecular and genetic keep watch over of oocyte improvement that may be utilized to fertility upkeep. the most themes which are mentioned during this book contain molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.
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Additional info for Oocyte Biology in Fertility Preservation
2002), bone morphogenic protein 7 (BMP-7) (Lee et al. 2001, 2004), BMP-4 (Nilsson and Skinner 2003), and growth differentiation factor 9 (GDF-9) (Hreinsson et al. 2002; Martins et al. 2008; Vitt et al. 2000) enhance the activation of primordial follicles in vitro. Similarly, Smad3 (Tomic et al. 2004) and growth hormone (Slot et al. 2006) also enhance follicular activation in mice In Vitro Activation of Dormant Follicles Organ or Cortical Strip Culture The initial activation and the sustained in vitro growth of the most abundant dormant follicles are crucial to maximizing the reproductive potential of cryopreserved or fresh ovarian tissue.
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Oocyte Biology in Fertility Preservation by S. Samuel Kim M.D., F.A.C.O.G. (auth.), S. Samuel Kim (eds.)