Oncogenes and Growth Control by Patricia Kahn, Thomas Graf PDF
By Patricia Kahn, Thomas Graf
How is progress managed in basic cells? How are the expansion keep watch over mechanisms perturbed in melanoma cells? This e-book offers an updated description of study aimed toward resolving those questions. it's equipped into 4 sections, each one containing a chain of brief experiences written by means of specialists within the box. the overall headings are: development components, receptors, and comparable oncogenes: transduction of mitogenic indications and ras oncogenes; nuclear oncogenes and legislation of gene expression; and a number of steps enthusiastic about malignant transformation. The articles emphasize ideas instead of exact proof and are meant not just for experts within the box but additionally for readers, reminiscent of physicians and complicated scholars, who desire to remain abreast of advancements in a single of the main fascinating fields in present biomedical research.
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Rizzino and BowenPope (1985) reported that differentiation of F9 cells resulted in a 30-fold increase in the binding ofPDGF, while Gudas et al. (1983) detected only a twofold increase. However, the latter authors observed a 20- to 30-fold increase in PDGF binding by PSA-1-G-derived fibroblast-like cells. These data suggest that the expression of PDGF-like molecules and PDGF receptors is not characteristic of pluripotent stem cells but might be induced upon differentiation. Embryonal Carcinoma-Derived Growth Factors Since identification and isolation of growth factors directly from the embryo is very difficult, investigators have turned to EC cells as an alternative source.
Acknowledgments. The authors are very grateful to Drs. Norman Iscove, Colin Stewart and Ulrich Ruther for critically reading the manuscript and to Ines Benner for typing. References Adams 1M, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, Brinster RL (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318:533 - 538 26 E. F. Wagner and R. Muller: A Role for Proto-Oncogenes in Differentiation? Alema S, Casalbore P, Agostini E, Tato F (1985) Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene.
Other EC cell lines, such as F9, PC13, and OC1S, release factors that promote the growth of NRK cells in soft agar (Rizzino et al. 1983), but are unrelated to the defined TOFs. Proper et al. (1982) have characterized a transforming growth factor from extracts of 17-day-old embryos which is unrelated to TOF-a. The nature of these activities can only be assessed after their purification. Concluding Remarks Our understanding of the role that growth factors play in mouse embryogenesis is still in a very preliminary phase.
Oncogenes and Growth Control by Patricia Kahn, Thomas Graf