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Additional resources for Modell's Drugs in Current Use and New Drugs, 2006: 52nd Edition (Modell's Essential Drugs in Current Use and New Drugs)

Example text

Acute bacterial sinusitis: 800 mg once daily ϫ5 days. Community acquired pneumonia: 800 mg once daily ϫ7–10 days. Dosage adjustment for hepatic impairment: not necessary. Dosage adjustment for renal impairment (creatinine clearance Ͻ30 mL/min) or patients on dialysis: dose of telithromycin has not been established. PATIENT CARE IMPLICATIONS Telithromycin may cause problems with vision. indd 40 12/21/05 3:11:00 PM TINIDAZOLE • 41 or engaging in hazardous activities. Patients should be informed to report any fainting occurring during drug treatment.

ADMINISTRATION Do not administer within 24 hours of chemotherapy. Adults: IV: 60 mcg/kg/day for 3 consecutive days before and after myelotoxic therapy. Total of 6 doses. The third dose of premyelotoxic therapy should be given 24 –48 hours before myelotoxic therapy begins. The first of the last 3 doses should be administered on the same day of (but after) hematopoietic stem cell infusion. Administer by IV bolus. Once vial is reconstituted with sterile water do not shake or vigorously agitate the vial.

PRECAUTIONS/ADVERSE REACTIONS Tinidazole is contraindicated in persons hypersensitive to tinidazole, other nitroimidazole derivatives, or any component of the formulation. Tinidazole is contraindicated during the first trimester of pregnancy. Warning: Convulsive seizures and peripheral neuropathy (mainly numbness or paresthesia of an extremity) have been reported with nitroimidazole drugs. Use with caution in patients with CNS diseases. Use with caution in patients with current or a history of blood dyscrasias; tinidazole may produce transient leukopenia and neutropenia.

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