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By H.-J. Merté (auth.), Prof. Dr. Hanns-Jürgen Merté (eds.)
After a compound and its a variety of results - or, because the case will be, any specific this type of - were chanced on there's nonetheless some distance forward till it truly is on hand to be used in day-by-day perform as a comprehensive product. earlier than achieving the health practitioner, the substance is tested by way of chemists, pharmacologists and pharmacists - simply to point out many of the most vital phases in a complete learn series. earlier than the drug is eventually made on the market, the findings caused by animal experiments needs to be proven in medical reports. the expectancies all for its improvement has to be met, and enough proof should be validated as to the drug's results and unintended effects, symptoms and contraindications, and the questions of secure use and applicable dosage. basically then may possibly the drug be registered and brought to the marketplace. during this appreciate Metipranolol eye drops, that have lately been introduced out there, shaped no exception and had likewise to head via a majority of these a variety of phases. a chain of investigators at many alternative facilities participated during this method, and on the invitation of the brands, Messrs. Dr. Gerhard Mann, they assembled for discussions at a symposium held in Berlin in January 1983, and mentioned at the substance and their reviews with it.
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Extra info for Metipranolol: Pharmacology of Beta-blocking Agents and Use of Metipranolol in Ophthalmology
Not only in glaucoma patients. Our own studies, carried out in cooperation with the first medical clinic of our university, plainly demonstrated such an effect upon the systemic administration of propranolol and metoprolol (Fig. 12). Furthermore it is worthy of note that beta-blocking agents do not show any effect on the width of pupil and accommodation. I I frequency r1ghl eye lelt eye •• • I I I I I I I I I I I I 0 - -1--2--3--4--5--6- -7--8--9--10--11--12-mmHg I I I I I I I I I I • t I I I t I I I I I I decrease rn tensron I Fig.
Und 26. ), pp. 63-68. Heidelberg: Rausch. 1982. 10. : Correlations between hydrophobicity and non-specific pharmacological effects of ,8-adrenoceptor blocking agents. Pol. J. Pharmacal. Pharm. 28, 625-630 (1976). 11. igbarkeit von Metipranolol bei Leberzirrhotikern unterschiedlichen Schweregrades. Dissertation, Berlin, 1981. 12. : Pharmakokinetik des j')-Rezeptorenblockers Metipranolol bei Patienten mit Leberzirrhose. Dtsch. med. Wschr. 107, 21-26 (1982). 13. Woods, P. , Robinson, M. : An investigation of the comparative liposolubilities of ,8-adrenoceptor blocking agents.
It is typical that the reduction in intraocular pressure occurs even after a single application , whereby there are distinct substance-specific differences in the intensity and duration of action [6-9] of the individual beta-receptor blocking agents. This is due to the fact that, apart from their specific beta-adrenolytical component of action, beta-receptor blocking agents possess more or less pronounced side effects which may restrict topical application and, also with regard to therapeutic aspects, this makes a comparison interesting.
Metipranolol: Pharmacology of Beta-blocking Agents and Use of Metipranolol in Ophthalmology by H.-J. Merté (auth.), Prof. Dr. Hanns-Jürgen Merté (eds.)