New PDF release: Menopause: Biology and Pathobiology


By Rogerio A. Lobo, Jennifer Kelsey, Robert Marcus

ISBN-10: 0080536204

ISBN-13: 9780080536200

ISBN-10: 0124537901

ISBN-13: 9780124537903

Menopause: Biology and Pathobiology is a accomplished quantity masking all facets of the biology, anatomy, body structure, pathobiology, and pharmacology of menopause, in addition to its prognosis and management.The booklet is split into 4 sections: simple Biology, Epidemiology, Menopausal structures Pathophysiology, and Intervention. easy Biology covers such basics as ovarian anatomy and body structure, mechanisms of steroid hormone motion, chronobiological results, and untimely menopause. Epidemiology contains, between others, chapters on technique demanding situations within the research of menopause, the best way to distinguish the consequences of age from these of menopause, and a dialogue of the main changes in demographics, environmental elements, and ethnicity within the menopause event. The Pathophysiology part includes chapters on menopause and its quite a few results at the physique, together with sexuality, epidermis, mind, the cardiovascular approach, cancers, and temper. the ultimate part contains precise chapters on intervention and administration options, with issues together with replacement remedies to hormone alternative, workout, and estrogens and osteoporosis. Key good points* offers a accomplished, research-oriented method of menopause* Covers every little thing from easy biology to pathophysiology to intervention treatments* Takes a multidisciplinary process that's worthy for researchers and clinicians in lots of fields * provides the most recent simple and scientific facts* comprises entire references that permit the reader to fast find appropriate details* Written and edited by way of precise specialists within the box

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Extra resources for Menopause: Biology and Pathobiology

Sample text

Battaglia, D. , and Soules, M. R. (1996). Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: A study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J. Clin. Endocrinol. Metab. 81, 2742 -2745. , and Kobayashi, M. (1992). Immunohistochemical localization of inhibin/activin subunits in human ovarian follicles during the menstrual cycle. J. Clin. Endocrinol. Metab. 74, 989-993. Roberts, V. , and EI-Roeiy, A.

Reprod. 5, 56-59. 8. , and Mayaux, M. J. (1982). Female fecundity as a function of age. N. Engl. J. Med. 306, 404-406. 9. Qasim, S. , Corsan, G. , and Kemmann, E. (1995). High-order oocyte transfer in gamete intrafallopian transfer patients 40 or more years of age. Fertil. Steril. 64, 107-110. 10. Penzias, A. , Thompson, I. , Alper, M. , Oskowitz, S. , and Berger, M. J. (1991). Successful use of gamete intrafallopian transfer does not reverse the decline in fertility in women over 40 years of age.

A smaller number of double-labeled cells are found in the medial preoptic area, and only a few double- CHAPTER3 Role of Gonadal Steroids in Menopause labeled cells are found in the ventromedial and arcuate nuclei of the hypothalamus. The consequences of this coexpression of the two ER subtypes are presently unknown; however, it is likely that cells that express one or both of the ER subtypes respond to estrogen differently. In addition, cells in which ERa and ERfl are expressed may express an array of genes that could be activated by the heterodimer a/fl (see Section II,A).

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Menopause: Biology and Pathobiology by Rogerio A. Lobo, Jennifer Kelsey, Robert Marcus

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