Download e-book for kindle: Lidocaine - A Medical Dictionary, Bibliography, and by Icon Health Publications
By Icon Health Publications
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Additional resources for Lidocaine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
We propose to evaluate various doses of the sodium channel antagonist lidocaine, when given in combination with varying doses of the NMDA receptor antagonist dextromethorphan, in patients with spontaneous pain and touch-evoked allodynia following SCI. Our primary aim is to determine the best dose-ratio of the two drugs in order to design efficiently the definitive phase III clinical trial evaluating the combination of these two classes of drugs, compared to placebo and each individual component drug.
The results of the studies in this grant proposal should further our understanding of the molecular mechanisms of cardiac Na channel function, and help determine which components of the channel's voltage sensors are modified by lidocaine. ; Associate Professor; University of Southern California 2250 Alcazar Street, Csc-219 Los Angeles, Ca 90033 Timing: Fiscal Year 2002; Project Start 01-DEC-2001; Project End 30-NOV-2002 Summary: This abstract is not available. Generate_Screen 30 • Lidocaine Project Title: PROCESSING OF BILATERAL INPUTS TO VESTIBULAR NUCLEUS Principal Investigator & Institution: Ariel, Michael; Associate Professor; Anatomy and Neurobiology; St.
E. the inactivation lid) is not required for local anesthetic drug modification of the putative voltage sensors in cardiac Na channels. 3. Demonstrate that lidocaine and local anesthetic drugs do not cause gating charge to become "immobilized" similar to that found for fast inactivated wildtype hHla channels. 4. e. the slow return of gating charge during repolarization) only after binding of an intact inactivation lid in Na channels. 5. Determine if the voltage sensor formed by the S4 segment in domains III contributes approximately 22 percent to the total Qmax of the cardiac Na channel.
Lidocaine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications