Download e-book for iPad: Karch's pathology of drug abuse by Steven B. Karch MD


By Steven B. Karch MD

ISBN-10: 0849303435

ISBN-13: 9780849303432

Written within the similar available demeanour as earlier versions, the 5th variation of Karch’s Pathology of Drug Abuse is a necessary advisor to the pathology, toxicology, and pharmacology of typically abused medicinal drugs. The booklet specializes in the research of drug-related deaths, functional methods to the detection of drug abuse, and discussions of scientific problems linked to all the abused drugs.

The 5th variation Now Features:

  • Completely revised with 1000s of pages of fully new coverage
  • Extensive dialogue of latest artificial cannabinoids and cathinone derivatives
  • Expanded assurance of the practical and molecular pharmacology of cocaine and myocardial remodeling
  • Expanded dialogue of deaths with regards to prescription medications
  • Detailed feedback at the interpretation of postmortem drug measurements
  • Many new excessive answer full-color photomicrographs
  • Additional, worthwhile new appendices on ordinary reference values

Separate chapters are dedicated to cocaine, clearly taking place stimulants, artificial stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The publication additionally bargains specified details at the origins, heritage, and creation strategies used to make lots of those medicinal drugs. up to date, revised, and newly illustrated, Karch’s Pathology of Drug Abuse, 5th Edition is a must have reference for learn and perform regarding drug abuse.

Steven B. Karch additionally discusses the e-book in a

video at the CRC Press YouTube channel.

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Extra info for Karch's pathology of drug abuse

Example text

Placing two drops of 4% cocaine on the skin, breathing deeply when spraying a patient with 4% cocaine aerosol, or squeezing cocainesoaked cotton pledgets between the fingers did not cause any of 11 volunteers to test positive (Zieske, 1992). In a 1994 study, three different scenarios were tested; the urine of physicians was tested after they had soaked cottonoid pledgets in a 4% cocaine solution and then inserted them into patients’ nares. The physicians wore masks for all the trials, but wore gloves for only six.

There were focal degenerative changes in the spinal ganglia, heart, and liver. In some cases, the myocytes had “lost their striae and [were] intensely granular” (Zanchevski, 1888). Although illustrations are lacking, Zanchevski’s descriptions suggest that he was the first to observe a form of contraction band necrosis (CBN) occurring as a result of cocaine toxicity. French researchers were the first to systematically study cocaine’s psychological effects, largely because cocaine and morphine addiction were such a major problem in Paris.

Levels after snorting are intermediate. 3 Coca tea drinking Coca teas are popular in many areas of South America and are even sold commercially. The average coca tea bag contains approximately 1 g of dried coca leaves. The content of the commercial tea bags is quite variable, depending on where they are manufactured. Products from Peru and Bolivia generally contain 1 g of dried, shredded coca leaf containing 4 to 5 mg of cocaine plus variable amounts of benzoylecgonine and ecgonine methyl ester, along with trace amounts of trans-cinnamoylcocaine.

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