New PDF release: Glutathione - A Medical Dictionary, Bibliography, and


By Icon Health Publications, Health Publica Icon Health Publications

ISBN-10: 0585495254

ISBN-13: 9780585495255

ISBN-10: 059783962X

ISBN-13: 9780597839627

It is a 3-in-1 reference booklet. It offers an entire clinical dictionary protecting countless numbers of phrases and expressions in terms of glutathione. It additionally supplies wide lists of bibliographic citations. eventually, it presents details to clients on tips on how to replace their wisdom utilizing numerous web assets. The ebook is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with learn devoted to glutathione. in case your time is efficacious, this e-book is for you. First, you won't waste time looking the web whereas lacking loads of correct info. moment, the publication additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing enormous quantities of web content.

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Extra resources for Glutathione - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Sample text

This approach is unique and allows for studies not previously possible. it was observed that the cytokine, interleukin 6, decreases the expression of a number of GST isozymes. The decrease in expression is mediated by elements in the promoter sequence of the GST gene and a unique nuclear protein has been identified that appears to mediate the decrease in transcription. This nuclear protein also is induced in the livers of animals during the acute phase response, and its appearance is associated with a decline in GST expression.

However, the results indicated that the factors governing protection by GST are complex and vary with different agents and endpoints. The studies outlined in this proposal will provide new information on the efficacy and specificity of human GSTP1 or GSTM1 protection against DNA adduct formation or cytotoxicity caused by exposure to PAHs activated in situ by co-expressed rat rCYP1A1 or human hCYP1A1. Heterologous expression of the GST isozymes in V79 cells previously stably transfected with rCYP1A1 or hCYP1A1 will be used as the experimental model system.

Further, we will delineate the roles of GCLC and GCLM in controlling GSH levels. These studies will provide valuable insight into understanding the etiology, preventive medicine, and the possible development of therapeutic intervention in the above-mentioned diseases and toxicities. For example, studies suggest that human genetic differences exist in toxicity to cadmium and other environmental toxicants that cause oxidative stress; moreover, the GCLC and GCLM genes are highly polymorphic. Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease.

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Glutathione - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications, Health Publica Icon Health Publications

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