Download e-book for iPad: FASTtrack: Pharmacology by Michael D. Randall


By Michael D. Randall

ISBN-10: 0853698244

ISBN-13: 9780853698241

It is a revision advisor for college kids giving bullet issues of easy details on pharmacology. "FASTtrack" is a brand new sequence of critical revision courses created in particular for undergraduate pharmacy scholars. uncomplicated info is equipped on all major components of research for the MPharm in small concise texts. each one name offers a precis of all key info besides diagrams, instances and questions and solutions for self evaluate. The books are functional, effortless to learn and well-priced and supplement textbooks and reduction scholars with revision for examinations. This particular identify is a uncomplicated revision advisor in Pharmacology masking all platforms within the physique. This revision consultant comprises mechanisms of motion, adversarial results and medical context for every drug workforce less than each one approach. most significantly this article is appropriate to clinical and pharmacy scholars alike, specially so, because it is written through teachers in pharmacology from the college of Nottingham clinical university who educate undergraduate clinical and pharmacy scholars. A FASTtrack web site contains MCQs, pattern on-line content material and lots more and plenty extra.

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Example text

They appear to concentrate in close proximity to CD36, which binds oxidised low-density lipoproteins on the cell surface, acting as a relay to intracellular enzymes or receptors, such as the peroxisome proliferatoractivated receptors (PPARs). 43 44 Pharmacology ATP-binding cassette transporters ABC transporters are probably the largest family of membrane transporters, able to regulate the flow of a huge array of both endogenous and exogenous substances, primarily out of the cell. Structurally, they have two domains of usually six transmembrane-spanning regions (unusually up to 11), with one or two intracellular nucleotide-binding domains (NBD).

Posttranslational modifications of G-proteins Prenylation ■ ■ ■ ■ ■ ■ Unsaturated hydrocarbon chain Farnesyl (C16) or geranylgeranyl (C21) For Ras, Rab and Rho, attached at C-terminus cys-AAX (where A is an aliphatic amino acid, such as valine, leucine or isoleucine), prior to cleavage of AAX Anchors Gc and low-molecular-weight G-proteins in the plasma membrane Activity of small G-proteins is dependent on prenylation and is an indirect means of regulating activity: ● inhibition of farnesyl/geranylgeranyl availability through inhibition of hydroxyglutarylmethyl-coenzyme A (HMG CoA) reductase by statins limits the function of small G-proteins Essentially irreversible.

DAG activates PKC, thereby leading to the phosphorylation of numerous target proteins, while IP3 allows the release of calcium from intracellular stores by acting on intracellular IP3 receptor ligand-gated channels. Elevation of intracellular calcium ions has regulatory effects on a wide range of cellular proteins (see below). Both IP3 and DAG can be modified for recycling to PIP2 or converted to other active entities. Extrusion of IP3 out of the cell also occurs, but the mechanism and physiological relevance are obscure.

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FASTtrack: Pharmacology by Michael D. Randall

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