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Additional resources for Evaluation of Certain Veterinary Drug Residues in Food: Fifty-Fourth Report of the Joint Fao Who Expert Committee on Food Additvives (Who Technical Report Series)

Example text

With the food bolus, by biliary circulation and/or by mucosal secretion) (recommendation 1(b))? Yes V Conclude that the drug residue will not affect the intestinal microflora and use toxicological data to derive the ADI (recommendation 1(a)). V Conclude that the drug residue will not affect the intestinal microflora and use toxicological data to derive the ADI (recommendation 1(b)). No is the ingested residue transformed irreversibly to inactive metabolites by chemical — transformation, metabolism mediated by the host or by the intestinal microflora in the bowel and/or by binding to intestinal contents (recommendations 1(b)-1(d))?

In response to the third request, a suitable analytical method was provided for quantifying the total residues resulting from the use of the cypermethrin formulation containing an 80:20 mixture of the cisand trans-isomers. Since the method uses gas chromatography, in which all the possible isomers co-elute, it can be used to quantify total residues resulting from the use of cypermethrin containing any ratio of cis- and trans-isomers. Since the Committee did not receive the required information and there was no indication that it would be provided in the future, the temporary MRLs recommended at the forty-seventh meeting were not extended.

Analytical methods The method used to measure residue depletion is based on gas chromatography with detection by electron capture (GC-ECD). Validation was provided for the analysis of cyhalothrin residues in edible tissues from cattle, pigs and sheep and in cows' milk. The method involves extraction of the sample, followed by solvent partitioning and solid-phase extraction for purification of the extracts. The choice of cartridge depends on the sample matrix and the detection system. The analytical recovery was 74-100%, depending on the sample matrix.

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