Download PDF by David O. Norris: Endocrine Disruption: Biological Bases for Health Effects in
By David O. Norris
This ebook addresses the organic results of the kind of huge variety of sessions of compounds which were famous as endocrine disrupters. those compounds were chanced on to persist as toxins within the surroundings, and feature been blamed for inflicting developmental issues and/or fertility difficulties in fish, amphibians, reptiles, birds, and doubtless people. This e-book offers the correct basics of the endocrine structures of animals and people, the toxicology, developmental toxicology, ecology, and probability review tools, and lays out the present country of figuring out for the complete box, equipped through the sessions of compounds which have been pointed out as endocrine disrupters.
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Additional resources for Endocrine Disruption: Biological Bases for Health Effects in Wildlife and Humans
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Similar to steroid hormone receptors, the activated nuclear AhR binds to promoter regions of a number of genes. These target genes may directly alter endocrine function or may induce expression of enzymes that metabolize the phenolic compounds themselves. EDCs may also bind to other types of receptors to produce endocrine disruption. , 2000). , endosulfan and other organochlorine pesticides) bind with high affinity to vertebrate neurotransmitter receptors (Bloomquist, 1996), such as g-aminobutyric acid (GABA)A receptors, and may alter endocrine function through this mechanism.
Endocrine Disruption: Biological Bases for Health Effects in Wildlife and Humans by David O. Norris