Download e-book for kindle: Chemokine Receptors as Drug Targets (Methods and Principles by Martine J. Smit, Sergio A. Lira, Rob Leurs, Raimund

Pharmacology

By Martine J. Smit, Sergio A. Lira, Rob Leurs, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

ISBN-10: 3527321187

ISBN-13: 9783527321186

Starting with a common advent on chemokine functionality and chemokine receptor biology, the instruction manual is going directly to disguise the identified implications of those signaling molecules in human illnesses, resembling melanoma, neural problems, and viral an infection, together with HIV/AIDS. the second one half the publication systematically surveys present drug improvement efforts at focusing on person chemokine receptors, in addition to different chemokine interplay companions. Contributions within the first a part of the ebook are commonly from academia, while the second one half comprises up to date stories from the pharmaceutical undefined.

Show description

Read or Download Chemokine Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry) PDF

Best pharmacology books

Download e-book for kindle: High-Yield Pharmacology (3rd Edition) (High-Yield Series) by Stephanie T. Weiss

Now in its 3rd version, High-Yield™ Pharmacology offers a succinct evaluation of pharmacology whereas clarifying tricky ideas. Need-to-know details is gifted in a transparent, concise define layout. extra gains contain up to date drug references, a drug index, key issues in daring, and tables summarizing key proof.

Read e-book online In Silico Methods for Predicting Drug Toxicity PDF

This designated quantity explores in silico tools for pharmaceutical toxicity via combining the theoretical complex examine with the sensible program of the instruments. starting with a piece masking subtle types addressing the binding to receptors, pharmacokinetics and adsorption, metabolism, distribution, and excretion, the publication keeps with chapters delving into types for particular toxicological and ecotoxicological endpoints, in addition to huge perspectives of the most tasks and new views to be able to almost certainly enhance our manner of modelling prescription drugs.

Extra info for Chemokine Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry)

Sample text

And Gearing, D. (1997) Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature, 387, 611–617. J. (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature, 385, 640–644. L. (1977) Amino acid sequence of human platelet factor 4. Proceedings of the National Academy of Sciences of the United States of America, 74, 2256–2258. V. (1985) Gamma-interferon transcriptionally regulates an early- response gene containing homology to platelet proteins. Nature, 315, 672–676.

Biochemistry, 43 (46), 14602–14611. A. C. (2009) Discovery of new GPCR biology: one j27 j 1 Structural Aspects of Chemokines and their Interactions with Receptors and Glycosaminoglycans 28 68 69 70 71 72 73 74 receptor structure at a time. Structure (London, England: 1993), 17 (1), 8–14. C. (2005) Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. The Journal of Biological Chemistry, 280, 34661–34666. B. (1991) Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding.

1988) Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. The Journal of Experimental Medicine, 167, 570–581. C. C. (1997) The chemokine information source: identification and characterization of novel chemokines using the j23 j 1 Structural Aspects of Chemokines and their Interactions with Receptors and Glycosaminoglycans 24 8 9 10 11 12 13 14 15 WorldWideWeb and expressed sequence tag databases. Journal of Leukocyte Biology, 61, 545–550.

Download PDF sample

Chemokine Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry) by Martine J. Smit, Sergio A. Lira, Rob Leurs, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers


by Jeff
4.1

Rated 4.31 of 5 – based on 9 votes