Download e-book for kindle: Calcium Antagonists: Pharmacology and Clinical Research by Olga Krizanova, Philippe Lory, Arnold Schwartz (auth.), T.
By Olga Krizanova, Philippe Lory, Arnold Schwartz (auth.), T. Godfraind, R. Paoletti, S. Govoni, P. M. Vanhoutte (eds.)
Although the significance of calcium (Ca2+) within the upkeep of cardiac contractility was once famous as early as 1880, the severe position of the ion within the contractile strategy in skeletal, cardiac, and soft muscle has in basic terms been tested in the final 3 decades.
because the complexity of the pharmacological activities of the Ca2+ channel inhibitors grows, there's a endured have to additional make clear the inhibitors, either chemically and functionally.
This quantity offers an replace of the sphere in line with the paintings offered on the fifth foreign Symposium on Calcium Antagonists:Pharmacology and medical Research. It stories the present nation of the starting to be quarter of molecular biology of Ca2+ channels. within the cardiovascular region, as well as the well-established medical makes use of of Ca2+ channel inhibitors, intriguing new paintings pointing to an program in atherosclerosis is defined. The e-book additionally contains very important makes use of of Ca2+ antagonists in novel components of curiosity reminiscent of the gastrointestinal tract, renal security and multi-drug resistance.
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Additional resources for Calcium Antagonists: Pharmacology and Clinical Research
16 L. G. HERBEITE ET AL. sarcolemmal membrane (3). Diffusion-limited rates calculated for a membrane pathway are approximately 3 orders of magnitude greater that those for an aqueous approach in which the drug reaches the receptor by diffusion through the bulk solvent (2). The two-dimensional component of this process, lateral diffusion through the bilayer, has a significant rate advantage if the ligand has the appropriate location and orientation for binding to the receptor site (4). Experimental support for the first step of this pathway, namely DHP partitioning to a discrete, time-averaged location in the membrane bilayer, has been shown using small-angle x-ray and neutron diffraction (1).
225: 27-32. 16. M. and Campbell KP. (1991): 1. BioI. , 266: 3287-3293. 17. , Hofmann F. and Dascal N. (1991): Science, 253: 1553-1557. 18. F. and Schwartz A. (1991): Proc. Natl. Acad. Sci. , (in press). 19. T. J BioI. , 265: 17786-17791. 20. P. M. (1991): Neuron, 7: 45-57. M. M. F. M. Gutierrez, J. Ma*, E. Rios*, and C. Mundina-Weilenmann Northwestern University Medical School 303 E. Chicago Avenue, Chicago, Illinois 60611 *Rush University Medical College 1750 W. Congress Parkway, Chicago, Illinois 60612 There are many types of voltage-activated Ca2 + channels that are found in a wide variety of excitable and nonexcitable cells.
Ca2 + channels in other types of cells are also believed to be regulated by a variety of G proteins and by protein phosphorylation catalyzed by a variety of protein kinases (1-4). Most of the evidence that supports both the phosphorylation and the G protein hypotheses comes from electrophysiological studies. We wished to provide further insight into these processes by defining the biochemical and molecular events that are responsible for receptor-mediated regulation of Ca2 + channels by protein phosphorylation.
Calcium Antagonists: Pharmacology and Clinical Research by Olga Krizanova, Philippe Lory, Arnold Schwartz (auth.), T. Godfraind, R. Paoletti, S. Govoni, P. M. Vanhoutte (eds.)